The champions that counter Vayne hardest in top lane are Malphite (39.28%), Quinn (41.22%) and Kayle (41.82%) — those are Vayne's own pooled win rates. The easiest matchups are K'Sante (57.67%), Ryze (57.38%) and Ambessa (56.26%).
71 researched matchup guides for Vayne in top lane, most-played first. Win rates are Vayne's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Vayne vs Garen | 45.67% | 4,395 | Leans Garen |
| Vayne vs Nautilus | 50.65% | 3,487 | Even |
| Vayne vs Graves | 51.7% | 3,420 | Leans Vayne |
| Vayne vs Yone | 50.53% | 3,291 | Even |
| Vayne vs Aatrox | 47.3% | 2,852 | Leans Aatrox |
| Vayne vs Darius | 55.5% | 2,789 | Vayne favoured |
| Vayne vs Malphite | 39.28% | 2,788 | Malphite favoured |
| Vayne vs Sion | 49.49% | 2,752 | Even |
| Vayne vs Sett | 49.58% | 2,739 | Even |
| Vayne vs Ornn | 47.97% | 2,716 | Leans Ornn |
| Vayne vs Renekton | 49.24% | 2,687 | Leans Renekton |
| Vayne vs Lucian | 51.46% | 2,666 | Leans Vayne |
| Vayne vs K'Sante | 57.67% | 2,502 | Vayne favoured |
| Vayne vs Sylas | 52.09% | 2,488 | Leans Vayne |
| Vayne vs Shen | 45.74% | 2,479 | Leans Shen |
| Vayne vs Karma | 53.18% | 2,403 | Leans Vayne |
| Vayne vs Riven | 44.24% | 2,213 | Riven favoured |
| Vayne vs Yorick | 45.81% | 2,054 | Leans Yorick |
| Vayne vs Dr. Mundo | 49.29% | 2,047 | Even |
| Vayne vs Yasuo | 52.68% | 1,978 | Leans Vayne |
| Vayne vs Teemo | 43.69% | 1,847 | Teemo favoured |
| Vayne vs Tryndamere | 47.35% | 1,827 | Leans Tryndamere |
| Vayne vs Akali | 47.06% | 1,776 | Leans Akali |
| Vayne vs Pantheon | 47.56% | 1,636 | Leans Pantheon |
| Vayne vs Zaahen | 48.67% | 1,576 | Leans Zaahen |
| Vayne vs Jayce | 48.54% | 1,570 | Leans Jayce |
| Vayne vs Jax | 47.82% | 1,539 | Leans Jax |
| Vayne vs Wukong | 50.1% | 1,531 | Even |
| Vayne vs Singed | 44.86% | 1,509 | Singed favoured |
| Vayne vs Galio | 53.6% | 1,485 | Leans Vayne |
| Vayne vs Tahm Kench | 48.66% | 1,457 | Leans Tahm Kench |
| Vayne vs Mordekaiser | 49.9% | 1,443 | Even |
| Vayne vs Volibear | 48.02% | 1,443 | Leans Volibear |
| Vayne vs Illaoi | 46.24% | 1,395 | Leans Illaoi |
| Vayne vs Urgot | 46.74% | 1,380 | Leans Urgot |
| Vayne vs Gangplank | 43.24% | 1,369 | Gangplank favoured |
| Vayne vs Olaf | 49.65% | 1,275 | Even |
| Vayne vs Vladimir | 45.62% | 1,234 | Leans Vladimir |
| Vayne vs Gnar | 51.72% | 1,160 | Leans Vayne |
| Vayne vs Locke | 50.69% | 1,156 | Even |
| Vayne vs Nasus | 47.35% | 1,094 | Leans Nasus |
| Vayne vs Irelia | 48.55% | 1,034 | Leans Irelia |
| Vayne vs Rumble | 48.92% | 1,016 | Leans Rumble |
| Vayne vs Camille | 52.05% | 1,001 | Leans Vayne |
| Vayne vs Warwick | 51.57% | 989 | Leans Vayne |
| Vayne vs Ambessa | 56.26% | 967 | Vayne favoured |
| Vayne vs Kayle | 41.82% | 911 | Kayle favoured |
| Vayne vs Ryze | 57.38% | 894 | Vayne favoured |
| Vayne vs Cho'Gath | 54.67% | 878 | Leans Vayne |
| Vayne vs Akshan | 48.51% | 872 | Leans Akshan |
| Vayne vs Fiora | 48.97% | 872 | Leans Fiora |
| Vayne vs Kassadin | 51.19% | 842 | Leans Vayne |
| Vayne vs Ziggs | 49.76% | 834 | Even |
| Vayne vs Mel | 55.28% | 814 | Vayne favoured |
| Vayne vs Poppy | 50% | 810 | Even |
| Vayne vs Aurora | 53.42% | 760 | Leans Vayne |
| Vayne vs Swain | 55.08% | 728 | Vayne favoured |
| Vayne vs Zac | 52.44% | 698 | Leans Vayne |
| Vayne vs Lillia | 54.29% | 676 | Leans Vayne |
| Vayne vs Gragas | 51.04% | 625 | Leans Vayne |
| Vayne vs Quinn | 41.22% | 621 | Quinn favoured |
| Vayne vs Neeko | 52.61% | 593 | Leans Vayne |
| Vayne vs Gwen | 50% | 582 | Even |
| Vayne vs Sejuani | 51.3% | 540 | Leans Vayne |
| Vayne vs Maokai | 50.49% | 509 | Even |
| Vayne vs Kennen | 45.71% | 501 | Leans Kennen |
| Vayne vs Master Yi | 48.75% | 480 | Leans Master Yi |
| Vayne vs Kled | 49.77% | 438 | Even |
| Vayne vs Cassiopeia | 53% | 417 | Leans Vayne |
| Vayne vs Trundle | 53.2% | 344 | Leans Vayne |
| Vayne vs Heimerdinger | 42.94% | 333 | Heimerdinger favoured |