How to win lane as Vayne against Nasus · 46.59% win rate over 996 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne out-ranges Nasus at level 1 and denies his Q last-hits. |
| Level 2 | Vayne | Silver Bolts online at 2 lets Vayne chunk his HP faster than he can stack. |
| Level 3 | Vayne | Level 3 Silver Bolts true damage shreds his tanky start while you kite Q. |
| Levels 4-5 | Vayne | Vayne keeps kiting Wither with Tumble and out-damages his stacking. |
| Level 6 | Vayne | Final Hour's stealth and resets let Vayne dodge Wither and dominate. |
| First item | Vayne | BORK plus Silver Bolts melts stacked HP no tank item can outheal. |
| Two+ items | Vayne | Percent-HP W procs delete even a max-stack Nasus in extended fights. |
You out-range and out-trade Nasus from level 1 — poke him with Q autos, deny his early Q last-hits, and he has no answer but to farm passively while you build your lead.
The full Vayne vs Nasus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Nasus vs Vayne guide →
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