How to win lane as Vayne against Nasus · 47.35% win rate (1,094 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Kite him — W-shred his HP, deny his stacks.
Track: Nasus's W — Wither (15–11s cooldown). His only kite tool on you. Q-tumble out of it.
Read from Vayne's seat: which stage windows this plan plays for against Nasus.
This is Vayne's own plan; across 1,094 pooled games the lane is leaning Nasus.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne out-ranges Nasus at level 1 and denies his Q last-hits. |
| Level 2 | Vayne | Silver Bolts online at 2 lets Vayne chunk his HP faster than he can stack. |
| Level 3 | Vayne | At 3 Spirit Fire cuts your armour and Wither halves your kiting speed. |
| Levels 4-5 | Vayne | Wither is up every 15s at rank 1 and Tumble cannot outrun it. |
| Level 6 | Vayne | Fury of the Sands at 6 gives him range, resists and %HP damage. |
| First item | Vayne | His stacks outpace your first item; Soul Eater lifesteal holds. |
| Two+ items | Vayne | Percent-HP W procs delete even a max-stack Nasus in extended fights. |
You out-range and out-trade Nasus from level 1 — poke him with Q autos, deny his early Q last-hits, and he has no answer but to farm passively while you build your lead.
Pooled Emerald+ win rates from Vayne's side, sampled July 2026.
The full Vayne vs Nasus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Nasus, slightly — Vayne wins 47.35% of 1,094 games; winnable with the right plan.
Mostly — Nasus has a small statistical edge (52.65% win rate), but execution decides this lane far more than the pick does.
No — if anything Nasus has the slight edge (Vayne wins 47.35%), though it stays close.
Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Alacrity and Last Stand, and Resolve secondary (Bone Plating and Unflinching) vs Nasus.
Start Doran's Blade + Health Potion and back for Executioner's Calling (≈800g) — cuts his healing. Build Blade of the Ruined King (%HP duel spike) first, then Phantom Dancer, with Plated Steelcaps.
Playing the other side? Nasus vs Vayne guide →
All Vayne top lane matchups →
More Vayne top lane matchups: vs Master Yi · vs Mel · vs Mordekaiser · vs Nautilus · vs Neeko · vs Olaf