How to win lane as Vayne against Nautilus · 50.65% win rate over 3,487 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne out-ranges Nautilus at level 1 and punishes any hook whiff. |
| Level 2 | Vayne | Silver Bolts chunks his slow HP pool while you dodge Dredge Line. |
| Level 3 | Vayne | Level 3 true-damage procs shred his tanky start as you kite. |
| Levels 4-5 | Vayne | Vayne jukes hooks with Tumble and out-trades every missed Q. |
| Level 6 | Vayne | Final Hour stealth dodges Depth Charge and punishes its long cooldown. |
| First item | Vayne | BORK plus Silver Bolts melts his resists faster than he stacks them. |
| Two+ items | Vayne | Percent-HP W deletes tank Nautilus once his hook is on cooldown. |
You out-range Nautilus hard at level 1 — poke with Q autos, respect only his Dredge Line, and deny his shove since he can't threaten you without a hook.
The full Vayne vs Nautilus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Nautilus vs Vayne guide →
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