How to win lane as Vayne against Neeko · 52.61% win rate over 593 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is even — it hinges on landing or dodging Tangle-Barbs. |
| Level 2 | Vayne | Silver Bolts out-trades Neeko's autos once you're level 2. |
| Level 3 | Vayne | Level 3 keeps you ahead in autos while her root is on cooldown. |
| Levels 4-5 | Even / skill | Levels 4-5 are even as she farms toward her Pop Blossom spike. |
| Level 6 | Neeko | Neeko's level-6 Pop Blossom burst plus root can kill you outright. |
| First item | Vayne | BORK lets Vayne out-burst her squishy frame and Condemn her ult. |
| Two+ items | Vayne | Percent-HP W deletes squishy Neeko once you dodge her engage. |
It's a skill matchup at level 1 — dodge Tangle-Barbs and you win autos, eat the root and you take her whole combo, so the lane hinges on that one skillshot.
The full Vayne vs Neeko report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Neeko vs Vayne guide →
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