How to win lane as Vayne against Mordekaiser · 56.69% win rate over 1,443 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | You kite his slow Mace of Spades (Q) and win the level-1 trade. |
| Level 2 | Vayne | At level 2 he still can't catch you without landing Death's Grasp (E). |
| Level 3 | Mordekaiser | Level 3 is his spike — full kit and Indestructible (W) shield let him burst a pulled target. |
| Levels 4-5 | Vayne | You reclaim the trade at 4-5 by spacing his cooldowns before his ult. |
| Level 6 | Mordekaiser | Realm of Death (R) at 6 isolates you in a 1v1 where he stat-checks you. |
| First item | Vayne | Blade of the Ruined King's %HP true damage shreds his shield stats first item. |
| Two+ items | Vayne | Final Hour and true damage let you out-scale and beat him even inside his ult late. |
You win the first two levels by kiting his slow Mace of Spades (Q) and spacing his Death's Grasp (E) pull. His threat is purely walk-up, so keep your distance and Silver Bolts punishes him whenever he steps up to farm.
The full Vayne vs Mordekaiser report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Mordekaiser vs Vayne guide →
All Vayne top lane matchups →