Vayne vs Mordekaiser — Top Lane Matchup Guide

How to win lane as Vayne against Mordekaiser · 49.9% win rate (1,443 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15

Verdict: A genuine skill matchup — 49.9% win rate over 1,443 games, decided window to window rather than at champion select.

At a glance

Condemn his E-pull, %-true melts him through the W-shield, and kite the realm — he can't catch you once you space.

Track: Mordekaiser's R — Realm of Death (140–100s cooldown). His 1v1 realm — you can’t kite in it. Respect it.

Do

  • Build MR
  • Condemn his E-pull
  • Kite when his R is down

Don't

  • Get R’d into a 1v1
  • Stand in his E pull
  • Get caught flat-footed

Runes & build vs Mordekaiser

Start
Doran's Blade + Health Potion
First back
Executioner's Calling (≈800g) — cuts his healing
First item
Blade of the Ruined King (%HP duel spike)
Then
Phantom Dancer
Boots
Mercury's Treads
Runes
Lethal Tempo (Precision): Triumph, Legend: Alacrity, Last Stand · Resolve: Bone Plating, Unflinching · Shards: Adaptive Force, Adaptive Force, Magic Resist

Favour timeline — the windows in Vayne's game plan

Read from Vayne's seat: which stage windows this plan plays for against Mordekaiser.

This is Vayne's own plan; across 1,443 pooled games the lane is even.

StageFavouredWhy
Level 1VayneObliterate (Q) reaches 675 while you must walk to 550 to trade.
Level 2VayneDeath's Grasp (E) pulls from 700 into Obliterate and Darkness Rise.
Level 3MordekaiserLevel 3 is his spike — full kit and Indestructible (W) shield let him burst a pulled target.
Levels 4-5VayneObliterate falls to 5s at rank 4 and Death's Grasp to 10s — no gaps.
Level 6MordekaiserRealm of Death (R) at 6 isolates you in a 1v1 where he stat-checks you.
First itemVayneBlade of the Ruined King's %HP true damage shreds his shield stats first item.
Two+ itemsVayneFinal Hour and true damage let you out-scale and beat him even inside his ult late.

How to beat Mordekaiser as Vayne: the early game

The first levels are spent kiting Obliterate (Q) at 675 and staying outside the 700-range Death's Grasp (E) pull. His threat is purely walk-up, so hold your distance and let Silver Bolts punish him whenever he steps up to farm.

Hardest and easiest matchups for Vayne in top lane

Pooled Emerald+ win rates from Vayne's side, sampled July 2026.

Hardest

Easiest

Read the rest of this matchup

The full Vayne vs Mordekaiser report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Common questions

Who wins Vayne vs Mordekaiser in top lane?

Nobody on paper — a 49.9% win rate over 1,443 games makes this a coin flip decided by play, not champion select.

Is Vayne vs Mordekaiser a skill matchup?

Yes — Vayne vs Mordekaiser is a genuine skill matchup: 49.9% win rate, and the favour swings window to window rather than being set at champion select.

Does Vayne counter Mordekaiser?

No hard counter either way — the Vayne vs Mordekaiser win rate is 49.9%, an even lane decided by execution.

What runes does Vayne take vs Mordekaiser?

Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Alacrity and Last Stand, and Resolve secondary (Bone Plating and Unflinching) vs Mordekaiser.

What should Vayne build vs Mordekaiser?

Start Doran's Blade + Health Potion and back for Executioner's Calling (≈800g) — cuts his healing. Build Blade of the Ruined King (%HP duel spike) first, then Phantom Dancer, with Mercury's Treads.

Related guides

Playing the other side? Mordekaiser vs Vayne guide →
All Vayne top lane matchups →

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