How to win lane as Mordekaiser against Vayne · 50.1% win rate over 1,443 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Neither has an all-in at level 1 — she can only poke at range and you have no Darkness Rise aura stacked yet, so just farm and set up your level 2 spike. |
| Level 2 | Mordekaiser | Q + W online: single-target Obliterate poke and W shield sustain out-trade her low early autos before she owns a crit item to kite with. |
| Level 3 | Mordekaiser | With Q, W and E started your trades grind her down — land E on a tumble and your Darkness Rise aura punishes any extended fight she takes. |
| Levels 4-5 | Mordekaiser | Realm of Death drops her into a 1v1 with no wall for her Condemn and no team to peel, and you keep her stolen stats if you finish — your guaranteed kill window flips the lane. |
| Level 6 | Mordekaiser | Your magic first-item spike plus E pull and Death's Grasp magic pen glue her to your aura and lethal all-in before her own first crit item fully comes online. |
| First item | Vayne | She tips the lane at two items: Silver Bolts' percent-HP true damage ignores your shield and HP stacking, and tumble + invis lets her kite your slow Q while you fall behind in DPS. |
| Two+ items | Vayne | She out-scales hard late: percent-HP true damage shreds your tankiness, Condemn punishes facechecks, and she kites your slow telegraphed Q all day — play the pick, not the chase. |
"At level 1 you both just farm — neither has a real all-in, so soak the wave and don't chase a tumble you can't catch with no aura up yet. Your spike is level 2-3: once Q Obliterate and W Indestructible are online, your single-target poke plus banked shield out-trade her short early autos, and she has no crit item yet to kite you safely. Punch in when she steps up to last-hit, land Q for the single-target bonus and a Darkness Rise stack, and bank W damage so a returned Silver Bolts proc just refills your heal. Save E to yank her if she tumbles toward you."
The full Mordekaiser vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Mordekaiser guide →
All Mordekaiser top lane matchups →