How to win lane as Vayne against Pantheon · 52.07% win rate over 916 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Pantheon | Pantheon's Comet Spear poke and passive block win the level-1 trade. |
| Level 2 | Pantheon | His spear poke keeps chunking Vayne before Silver Bolts matters. |
| Level 3 | Pantheon | Level 3 Shield Vault stun all-in bursts Vayne down hard. |
| Levels 4-5 | Pantheon | Pantheon's poke and stun keep him ahead through levels 4-5. |
| Level 6 | Pantheon | Grand Starfall lets him dive and his stun ignores Vayne's kiting. |
| First item | Pantheon | His flat burst still out-trades Vayne before her BORK spike lands. |
| Two+ items | Vayne | Full-item range and percent-HP W finally let Vayne out-scale him. |
Pantheon crushes the early lane — Comet Spear out-pokes your autos, his passive blocks your poke back, and a level-3 Shield Vault all-in can nearly kill you outright.
The full Vayne vs Pantheon report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Pantheon vs Vayne guide →
All Vayne top lane matchups →