How to win lane as Nasus against Vayne · 52.65% win rate (1,094 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
She kites and true-damages you — Wither her, build resists, all-in early.
Track: Vayne's E — Condemn (20–12s cooldown). Wall-stun. Wither her so she can’t kite.
Read from Nasus's seat: which stage windows this plan plays for against Vayne.
This is Nasus's own plan; across 1,094 pooled games the lane is leaning Nasus.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne owns level 1 — her tumble plus Silver Bolts poke you off Q farm while you have no Wither to answer. |
| Level 2 | Even / skill | Still close to even but skill-based: you hoard Q stacks and dodge her tumble poke, neither of you can commit a kill yet. |
| Level 3 | Nasus | Wither comes online and halves her move and attack speed, killing her kite so you can walk down a tumble-happy Vayne. |
| Levels 4-5 | Nasus | You out-sustain her poke with Soul Eater while Spirit Fire's armor shred and DoT grind her down between Withers. |
| Level 6 | Nasus | Fury of the Sands plus Wither plus empowered Q bursts an item-less Vayne before she can kite or condemn free. |
| First item | Nasus | Your Sheen/Iceborn Q spike one-shots her off any Wither catch before Botrk and Shieldbow come online. |
| Two+ items | Vayne | She out-scales hard — Silver Bolts true damage shreds your HP bar and condemn kites your single-target ult, so close it early. |
Levels 1-2 are hers — her Q tumble plus Silver Bolts let her poke you off Q farm while you have no Wither to punish her, so just soak stacks with Siphoning Strike and eat a little chip. The lane flips at 3 the second Wither comes online: point-and-click slam her move and attack speed to a crawl, and a Vayne who can't tumble-kite is suddenly a free target. Don't waste Wither on poke — hold it for when she steps up to last-hit or commits a tumble.
Pooled Emerald+ win rates from Nasus's side, sampled July 2026.
The full Nasus vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Nasus, slightly — a 52.65% win rate edge over 1,094 games; execution can flip it.
Mostly — Nasus has a small statistical edge (52.65% win rate), but execution decides this lane far more than the pick does.
Not a hard counter — Nasus has a slight edge (52.65% win rate), and play quality decides the rest.
Nasus takes Fleet Footwork on the Precision tree with Triumph, Legend: Haste and Last Stand, and Resolve secondary (Second Wind and Unflinching) vs Vayne.
Start Doran's Shield + Health Potion and back for Sheen (≈900g) — every Q after this hits twice as hard. Build Trinity Force (Iceborn Gauntlet if you need the slow + armor) first, then Frozen Heart (her attack speed dies here), with Plated Steelcaps.
Playing the other side? Vayne vs Nasus guide →
All Nasus top lane matchups →
More Nasus top lane matchups: vs Trundle · vs Tryndamere · vs Urgot · vs Vladimir · vs Volibear · vs Warwick