How to win lane as Vayne against Cassiopeia · 53% win rate (417 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Weather the poke — kite her apart with tumble + true damage.
Track: Cassiopeia's W — Miasma (24–16s cooldown). Grounds you — dashes and movement abilities are disabled inside it.
Read from Vayne's seat: which stage windows this plan plays for against Cassiopeia.
This is Vayne's own plan; across 417 pooled games the lane is leaning Vayne.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Cassiopeia | Cassiopeia's early Q poke and grounding W edge the level-1 lane. |
| Level 2 | Even / skill | At 2 you get Silver Bolts and the exchange evens out. |
| Level 3 | Vayne | Level 3 her lack of a dash lets you walk her down between casts. |
| Levels 4-5 | Vayne | Levels 4-5 your AS and mobility keep you on top of her. |
| Level 6 | Cassiopeia | Petrifying Gaze at 6 stuns and swings the fight if you face her. |
| First item | Vayne | Blade of the Ruined King lets you close and %HP shred her escapeless frame. |
| Two+ items | Vayne | With 2+ items and Final Hour you kite and true-damage her down. |
Cassiopeia edges level 1 with early Q poke and her grounding W, so respect her range and don't walk into Miasma. Level 2 evens out as you get Silver Bolts and can start trading back.
Pooled Emerald+ win rates from Vayne's side, sampled July 2026.
The full Vayne vs Cassiopeia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Vayne, slightly — a 53% win rate edge over 417 games; execution can flip it.
Mostly — Vayne has a small statistical edge (53% win rate), but execution decides this lane far more than the pick does.
Not a hard counter — Vayne has a slight edge (53% win rate), and play quality decides the rest.
Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Alacrity and Last Stand, and Resolve secondary (Second Wind and Bone Plating) vs Cassiopeia.
Start Doran's Shield + Health Potion (vs her poke) and back for Core component + boots (≈1300g). Build Blade of the Ruined King (%HP duel spike) first, then Phantom Dancer, with Mercury's Treads.
Playing the other side? Cassiopeia vs Vayne guide →
All Vayne top lane matchups →
More Vayne top lane matchups: vs Ambessa · vs Aurora · vs Camille · vs Cho'Gath · vs Darius · vs Dr. Mundo