How to win lane as Vayne against Cassiopeia · 53% win rate over 417 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Cassiopeia | Cassiopeia's early Q poke and grounding W edge the level-1 lane. |
| Level 2 | Even / skill | At 2 you get Silver Bolts and the exchange evens out. |
| Level 3 | Vayne | Level 3 her lack of a dash lets you walk her down between casts. |
| Levels 4-5 | Vayne | Levels 4-5 your AS and mobility keep you on top of her. |
| Level 6 | Cassiopeia | Petrifying Gaze at 6 stuns and swings the fight if you face her. |
| First item | Vayne | Blade of the Ruined King lets you close and %HP shred her escapeless frame. |
| Two+ items | Vayne | With 2+ items and Final Hour you kite and true-damage her down. |
Cassiopeia edges level 1 with early Q poke and her grounding W, so respect her range and don't walk into Miasma. Level 2 evens out as you get Silver Bolts and can start trading back.
The full Vayne vs Cassiopeia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Cassiopeia vs Vayne guide →
All Vayne top lane matchups →