How to win lane as Vayne against Dr. Mundo · 54.91% win rate over 1,506 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | You dodge his slow Bonesaw and punish his immobility from level 1. |
| Level 2 | Vayne | At 2 your Silver Bolts already threaten his HP he can't protect. |
| Level 3 | Vayne | Level 3 Tumble spaces his poke while you keep proccing W. |
| Levels 4-5 | Vayne | Through 4-5 his cleaver slow can't catch you and true damage mounts. |
| Level 6 | Vayne | R Maximum Dosage is just more health for your true damage to eat. |
| First item | Vayne | First item Botrk makes his stacked HP your damage engine. |
| Two+ items | Vayne | At two items Final Hour and true damage delete him faster than he heals. |
Dr. Mundo throws slow, telegraphed Q Bonesaws and has no gap-closer at level 1-2, so you step around them with Tumble and freely start stacking Silver Bolts on him.
The full Vayne vs Dr. Mundo report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Dr. Mundo vs Vayne guide →
All Vayne top lane matchups →