How to win lane as Vayne against Vladimir · 45.62% win rate (1,234 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
He out-sustains + pools your burst — build MR, play safe.
Track: Vladimir's W — Sanguine Pool (28–16s cooldown). Dodges your burst. Bait it.
Read from Vayne's seat: which stage windows this plan plays for against Vladimir.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vladimir | Level 1 is Vladimir's — Transfusion sustains through any trade you attempt. |
| Level 2 | Vladimir | Level 2 stays his as his Q healing snowballs the poke war. |
| Level 3 | Vladimir | Level 3 favors Vladimir: Sanguine Pool dodges your Condemn engage entirely. |
| Levels 4-5 | Vladimir | Levels 4-5 remain red because his sustain out-heals your early burst. |
| Level 6 | Vladimir | Level 6 is firmly his with the Hemoplague amp-and-heal all-in. |
| First item | Vladimir | At first item his stacking HP and Q still out-heal your Silver Bolts. |
| Two+ items | Vayne | Only at two-plus items do Final Hour and percent-HP true damage finally outscale him. |
Levels 1-2 are already Vladimir's: Transfusion heals him through anything you throw, and you have no way to punish a champion who out-sustains your entire trade pattern. Concede the poke war, focus CS, and don't hand him kill pressure into his scaling.
Pooled Emerald+ win rates from Vayne's side, sampled July 2026.
The full Vayne vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Vladimir, slightly — Vayne wins 45.62% of 1,234 games; winnable with the right plan.
Mostly — Vladimir has a small statistical edge (54.38% win rate), but execution decides this lane far more than the pick does.
No — if anything Vladimir has the slight edge (Vayne wins 45.62%), though it stays close.
Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Alacrity and Last Stand, and Resolve secondary (Second Wind and Bone Plating) vs Vladimir.
Start Doran's Shield + Health Potion (vs his poke) and back for Executioner's Calling (≈800g) — cuts his healing. Build Blade of the Ruined King (%HP duel spike) first, then Phantom Dancer, with Mercury's Treads.
Playing the other side? Vladimir vs Vayne guide →
All Vayne top lane matchups →
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