How to win lane as Vladimir against Vayne · 51.22% win rate over 939 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vladimir | Vayne must enter your E-Q range to farm, so you control the level-1 poke. |
| Level 2 | Even / skill | Her level-2 Q Tumble trades are real, making the exchange skill-dependent. |
| Level 3 | Even / skill | Level 3 stays skill-based as she can tumble-auto and reposition out of your Q. |
| Levels 4-5 | Vladimir | By levels 4-5 your poke and healing clearly outpace her sustainless trades. |
| Level 6 | Vladimir | Hemoplague plus your burst can kill her outright at level 6. |
| First item | Vladimir | Your first AP item hard-outdamages her early tumble pattern. |
| Two+ items | Vladimir | In a lane trade your scaling burst beats her before Final Hour ramps. |
You have the upper hand at level 1 — Vayne has to come into your E-Q range to farm, and her early trades hurt but leave her low without sustain. Poke her with Q Transfusion and E Tides of Blood whenever she steps up. The level 2-3 window is skill-based since her Q Tumble auto-reset trades are real, but if you respect Condemn you come out ahead. Don't get pinned to a wall by her E.
The full Vladimir vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Vladimir guide →
All Vladimir top lane matchups →