How to win lane as Vayne against Karma · 53.18% win rate over 2,403 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is a skill matchup: it hinges on whether you dodge Inner Flame. |
| Level 2 | Vayne | Level 2 favours you: no CC to stop you walking her down for Silver Bolts stacks. |
| Level 3 | Vayne | Level 3 favours you: you punish her long Mantra cooldown with Tumble trades. |
| Levels 4-5 | Even / skill | Levels 4-5 are even: her empowered poke trades roughly with your DPS windows. |
| Level 6 | Even / skill | Level 6 is even: Karma's ult only refreshes spells and gives her no kill combo. |
| First item | Vayne | First item favours you: BotRK DPS shreds her weak base defenses in trades. |
| Two+ items | Vayne | Two-plus items favour you: you out-carry her utility role in every duel and fight. |
Level 1 is a skill check around dodging Karma's Inner Flame (Q): sidestep it with Tumble and the lane opens up immediately. She has no reliable hard CC and mediocre base defenses, so once you are level 2-3 you walk her down and stack Silver Bolts freely. Bait her Mantra-Q poke, then punish the long Mantra cooldown with a Tumble-auto trade. Only the Focused Resolve (W) tether threatens you, and it breaks on range.
The full Vayne vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karma vs Vayne guide →
All Vayne top lane matchups →