How to win lane as Karma against Vayne · 44.68% win rate over 47 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Mantra is up at level 1, so you open RQ Soulflare for a chunk-and-slow her auto-only early kit can't match — before Silver Bolts stack, you cleanly out-stat her. |
| Level 2 | Karma | Your Inner Flame poke layers onto Gathering Fire's Mantra refunds while she's still farming for attack speed — keep her low and deny the safe lane. |
| Level 3 | Karma | Multiple Q/RQ rotations push an immobile-early Vayne off the wave; she has no item sustain yet, so every poke sticks and you tax plates behind Inspire's speed. |
| Levels 4-5 | Vayne | Level 6 flips the lane: her Condemn stuns you into walls and Silver Bolts melt your support frame the moment your Inspire shield is down. |
| Level 6 | Vayne | Her first attack-speed item makes Silver Bolts' percent-max-HP true damage live — your poke no longer trades evenly and Tumble lets her kite your cooldowns. |
| First item | Vayne | After two items she out-trades everything Karma has: true-damage Silver Bolts plus Condemn-into-wall, and Tumble can break line of sight on your W tether. |
| Two+ items | Vayne | She out-scales hard with no answer from your kit — peel, don't duel; rely on your earlier lead, because every long fight past two items goes to Vayne. |
Levels 1-3 are yours and you must abuse them hard, because this lane only gets worse. Open with RQ Soulflare the second she walks up to last-hit — the delayed damage zone plus slow out-ranges her auto-only early kit and she has zero spell answer before Silver Bolts (W) ramp up. Layer Inner Flame (Q) poke on top and let Gathering Fire refund your Mantra cooldown so you can re-threaten the zone. Dodge her Tumble (Q) reposition, and if there's a wall behind you, respect Condemn (E) range — it means a stun into terrain. Build the biggest lead you can now; this is the only phase you cleanly out-stat her.
The full Karma vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Karma guide →
All Karma top lane matchups →