How to win lane as Vayne against Sett · 55.52% win rate over 1,740 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | At level 1 your range lets you poke before Sett's kit online. |
| Level 2 | Sett | Level 2 his fists and W punch out-trade you in melee. |
| Level 3 | Sett | Facebreaker (E) stun at 3 sets up his Haymaker all-in. |
| Levels 4-5 | Sett | Levels 4-5 his E-into-W combo chunks you hard. |
| Level 6 | Sett | The Show Stopper (R) at 6 suplexes and dives you. |
| First item | Vayne | First item the fight starts flipping as Silver Bolts ramps. |
| Two+ items | Vayne | At 2+ items true damage and Condemn hand you the 1v1. |
You actually win level 1 before his kit comes online; use your range to poke, but the moment he hits 2-3 with Haymaker (W) and Facebreaker (E), give ground.
The full Vayne vs Sett report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Sett vs Vayne guide →
All Vayne top lane matchups →