How to win lane as Vayne against Lillia · 54.29% win rate over 676 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Your Tumble burst beats her low base HP before Blooming Blows (Q) ramps. |
| Level 2 | Vayne | She has no early lockdown to punish your short trades at level 2. |
| Level 3 | Vayne | Level 3 kiting still favours you as her Q stacks reset out of combat. |
| Levels 4-5 | Even / skill | By levels 4-5 her ramped Q and disengage make trades a skill check. |
| Level 6 | Lillia | Her Lilting Lullaby (R) sleep comes online and threatens a full burst combo at 6. |
| First item | Vayne | Blade of the Ruined King offsets her passive burn and restores your DPS edge. |
| Two+ items | Vayne | Final Hour and %HP true damage let you out-scale her sustained combo late. |
You control the early game. Lillia has no point-and-click lockdown and low base HP, so Tumble-in trades favour you — two autos and a Silver Bolts proc beat her ramping Blooming Blows (Q) before it gets rolling.
The full Vayne vs Lillia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Lillia vs Vayne guide →
All Vayne top lane matchups →