The champions that counter Lissandra hardest in mid lane are Zoe (47.32%), Ziggs (47.42%) and Xerath (47.67%) — those are Lissandra's own pooled win rates. The easiest matchups are Yasuo (55.42%), Azir (54.9%) and Akali (54.72%).
46 researched matchup guides for Lissandra in mid lane, most-played first. Win rates are Lissandra's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Lissandra vs Yasuo | 55.42% | 14,384 | Lissandra favoured |
| Lissandra vs Zed | 51.35% | 12,586 | Leans Lissandra |
| Lissandra vs Sylas | 48.86% | 11,737 | Leans Sylas |
| Lissandra vs Ahri | 49.83% | 11,720 | Even |
| Lissandra vs Katarina | 50.68% | 10,857 | Even |
| Lissandra vs Viktor | 47.73% | 10,431 | Leans Viktor |
| Lissandra vs Syndra | 48.54% | 9,797 | Leans Syndra |
| Lissandra vs Fizz | 52.7% | 9,296 | Leans Lissandra |
| Lissandra vs Yone | 53.33% | 8,481 | Leans Lissandra |
| Lissandra vs Akali | 54.72% | 8,376 | Leans Lissandra |
| Lissandra vs LeBlanc | 53.32% | 7,177 | Leans Lissandra |
| Lissandra vs Xerath | 47.67% | 6,943 | Leans Xerath |
| Lissandra vs Naafiri | 52.29% | 6,936 | Leans Lissandra |
| Lissandra vs Lux | 51.5% | 6,629 | Leans Lissandra |
| Lissandra vs Malzahar | 49.42% | 6,435 | Even |
| Lissandra vs Hwei | 48.06% | 5,969 | Leans Hwei |
| Lissandra vs Twisted Fate | 49.8% | 5,851 | Even |
| Lissandra vs Vladimir | 49.39% | 5,665 | Even |
| Lissandra vs Diana | 51.36% | 5,621 | Leans Lissandra |
| Lissandra vs Talon | 51.28% | 4,824 | Leans Lissandra |
| Lissandra vs Karma | 52.26% | 4,772 | Leans Lissandra |
| Lissandra vs Irelia | 51.57% | 4,462 | Leans Lissandra |
| Lissandra vs Galio | 50.73% | 4,431 | Even |
| Lissandra vs Ekko | 49.72% | 4,288 | Even |
| Lissandra vs Mel | 54.63% | 3,967 | Leans Lissandra |
| Lissandra vs Veigar | 49.45% | 3,656 | Even |
| Lissandra vs Akshan | 51.22% | 3,520 | Leans Lissandra |
| Lissandra vs Orianna | 52.71% | 3,405 | Leans Lissandra |
| Lissandra vs Ryze | 51.76% | 3,333 | Leans Lissandra |
| Lissandra vs Qiyana | 51.89% | 3,207 | Leans Lissandra |
| Lissandra vs Kassadin | 49.9% | 3,120 | Even |
| Lissandra vs Ziggs | 47.42% | 3,045 | Leans Ziggs |
| Lissandra vs Zoe | 47.32% | 3,022 | Leans Zoe |
| Lissandra vs Anivia | 50.17% | 2,753 | Even |
| Lissandra vs Aurora | 51.62% | 2,716 | Leans Lissandra |
| Lissandra vs Vex | 50.18% | 2,668 | Even |
| Lissandra vs Pantheon | 54.49% | 2,571 | Leans Lissandra |
| Lissandra vs Annie | 49.95% | 2,358 | Even |
| Lissandra vs Brand | 51.65% | 2,238 | Leans Lissandra |
| Lissandra vs Swain | 52.47% | 2,211 | Leans Lissandra |
| Lissandra vs Cassiopeia | 49.87% | 1,564 | Even |
| Lissandra vs Aurelion Sol | 49.56% | 1,467 | Even |
| Lissandra vs Azir | 54.9% | 1,439 | Leans Lissandra |
| Lissandra vs Taliyah | 53.23% | 1,362 | Leans Lissandra |
| Lissandra vs Neeko | 52.75% | 1,327 | Leans Lissandra |
| Lissandra vs Locke | — | — | — |