How to win lane as Lissandra against Annie · 49.95% win rate (2,358 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Her burst needs a clean window — your root and tomb make every window cost a health bar.
Track: Annie's R — Summon: Tibbers (130–100s cooldown). Flash-Tibbers off a stocked passive stun is her whole threat — watch the glow under her feet.
Read from Lissandra's seat: which stage windows this plan plays for against Annie.
This is Lissandra's own plan; across 2,358 pooled games the lane is even.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is neutral farming with stun stacks still building. |
| Level 2 | Even / skill | Level 2 stays even as both trade minimally near stun range. |
| Level 3 | Even / skill | Level 3 trades are skill-based, gated by her passive versus your E range. |
| Levels 4-5 | Even / skill | Levels 4-5 remain matchup-neutral, decided by stun tracking. |
| Level 6 | Even / skill | At 6 your R survives or pre-empts her Tibbers combo for the edge. |
| First item | Lissandra | On first item your range and durability outlast her single all-in. |
| Two+ items | Even / skill | With two items your peel and lock beat her one-combo teamfight threat. |
Levels 1-2 are even farm but stun-stack aware; Annie will auto minions to build Pyromania, so watch her passive glow and hold your E, since neither of you kills without the jungler this early. Track Annie Pyromania: four casts stock the stun and Disintegrate is a 4s cooldown, so it recharges fast — watch the glow, not the cast. Annie's threat is her stun stacks: count her Pyromania passive and never walk into range at 4 stacks, but your E outranges her Q Disintegrate so you can poke her freely while her stun is charging.
Pooled Emerald+ win rates from Lissandra's side, sampled July 2026.
The full Lissandra vs Annie report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Nobody on paper — a 49.95% win rate over 2,358 games makes this a coin flip decided by play, not champion select.
Yes — Lissandra vs Annie is a genuine skill matchup: 49.95% win rate, and the favour swings window to window rather than being set at champion select.
No hard counter either way — the Lissandra vs Annie win rate is 49.95%, an even lane decided by execution.
Lissandra takes Electrocute on the Domination tree with Cheap Shot, Grisly Mementos and Ultimate Hunter, and Sorcery secondary (Manaflow Band and Transcendence) vs Annie.
Start Doran's Ring + 2 Health Potions and back for Lost Chapter (≈1300g) — steadies the Q-spam mana. Build Malignance first, then Zhonya's Hourglass, with Sorcerer's Shoes / Mercury's Treads.
Playing the other side? Annie vs Lissandra guide →
All Lissandra mid lane matchups →
More Lissandra mid lane matchups: vs Akali · vs Akshan · vs Anivia · vs Aurelion Sol · vs Aurora · vs Azir