Lissandra vs Annie — Mid Lane Matchup Guide

How to win lane as Lissandra against Annie · 51.69% win rate over 1,182 Emerald+ games · Updated 2026-07-27

Verdict: Lissandra is favoured — Lissandra owns 3 of the 7 game windows. Lissandra wins 51.69% of games vs Annie in mid lane (1,182 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1Even / skillLevel 1 is neutral farming with stun stacks still building.
Level 2Even / skillLevel 2 stays even as both trade minimally near stun range.
Level 3Even / skillLevel 3 trades are skill-based, gated by her passive versus your E range.
Levels 4-5Even / skillLevels 4-5 remain matchup-neutral, decided by stun tracking.
Level 6LissandraAt 6 your R survives or pre-empts her Tibbers combo for the edge.
First itemLissandraOn first item your range and durability outlast her single all-in.
Two+ itemsLissandraWith two items your peel and lock beat her one-combo teamfight threat.

Early game (levels 1–5)

Levels 1-2 are even farm but stun-stack aware; Annie will auto minions to build Pyromania, so watch her passive glow and hold your E, since neither of you kills without the jungler this early.

Read the rest of this matchup

The full Lissandra vs Annie report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Annie vs Lissandra guide →
All Lissandra mid lane matchups →