The champions that counter Annie hardest in mid lane are Diana (46.24%), Naafiri (46.39%) and Kassadin (46.63%) — those are Annie's own pooled win rates. The easiest matchups are Azir (57.36%), Ryze (56.73%) and Cassiopeia (56.6%).
46 researched matchup guides for Annie in mid lane, most-played first. Win rates are Annie's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Annie vs Ahri | 50.59% | 5,804 | Even |
| Annie vs Yasuo | 53.93% | 5,118 | Leans Annie |
| Annie vs Syndra | 47.93% | 4,778 | Leans Syndra |
| Annie vs Viktor | 51.31% | 3,816 | Leans Annie |
| Annie vs Katarina | 50.96% | 3,750 | Leans Annie |
| Annie vs Zed | 50.39% | 3,584 | Even |
| Annie vs Sylas | 49.79% | 3,469 | Even |
| Annie vs Yone | 54.36% | 3,287 | Leans Annie |
| Annie vs Akali | 52.57% | 2,950 | Leans Annie |
| Annie vs Lux | 50.94% | 2,711 | Leans Annie |
| Annie vs Xerath | 47.77% | 2,648 | Leans Xerath |
| Annie vs LeBlanc | 53.62% | 2,566 | Leans Annie |
| Annie vs Twisted Fate | 50.9% | 2,432 | Leans Annie |
| Annie vs Lissandra | 50.05% | 2,358 | Even |
| Annie vs Malzahar | 48.41% | 2,330 | Leans Malzahar |
| Annie vs Fizz | 49.8% | 2,307 | Even |
| Annie vs Akshan | 54.13% | 2,232 | Leans Annie |
| Annie vs Galio | 51.22% | 2,208 | Leans Annie |
| Annie vs Hwei | 51.25% | 2,194 | Leans Annie |
| Annie vs Vladimir | 48.01% | 2,193 | Leans Vladimir |
| Annie vs Karma | 54.84% | 1,962 | Leans Annie |
| Annie vs Diana | 46.24% | 1,864 | Leans Diana |
| Annie vs Talon | 49.97% | 1,745 | Even |
| Annie vs Veigar | 48.67% | 1,691 | Leans Veigar |
| Annie vs Irelia | 52.46% | 1,666 | Leans Annie |
| Annie vs Ryze | 56.73% | 1,643 | Annie favoured |
| Annie vs Zoe | 52.32% | 1,619 | Leans Annie |
| Annie vs Ekko | 48.85% | 1,609 | Leans Ekko |
| Annie vs Vex | 54.79% | 1,575 | Leans Annie |
| Annie vs Orianna | 53.96% | 1,503 | Leans Annie |
| Annie vs Mel | 55.25% | 1,439 | Annie favoured |
| Annie vs Aurora | 50.62% | 1,373 | Even |
| Annie vs Naafiri | 46.39% | 1,261 | Leans Naafiri |
| Annie vs Qiyana | 50.84% | 1,184 | Leans Annie |
| Annie vs Anivia | 53.06% | 1,176 | Leans Annie |
| Annie vs Kassadin | 46.63% | 1,128 | Leans Kassadin |
| Annie vs Brand | 52.69% | 983 | Leans Annie |
| Annie vs Ziggs | 50.34% | 898 | Even |
| Annie vs Azir | 57.36% | 727 | Annie favoured |
| Annie vs Taliyah | 51.85% | 621 | Leans Annie |
| Annie vs Aurelion Sol | 49.63% | 540 | Even |
| Annie vs Cassiopeia | 56.6% | 530 | Annie favoured |
| Annie vs Neeko | 54.04% | 507 | Leans Annie |
| Annie vs Swain | 47.9% | 309 | Leans Swain |
| Annie vs Pantheon | 50.87% | 287 | Leans Annie |
| Annie vs Locke | — | — | — |