How to win lane as Annie against Karma · 54.91% win rate over 1,914 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Level 1 favors Karma since her Mantra-Q poke chips you with no punish available. |
| Level 2 | Karma | Level 2 stays Karma-favored as she continues to out-range and out-poke your early trades. |
| Level 3 | Karma | Level 3-5 is still Karma's window — shield sustain and ranged harass deny your farm safely. |
| Levels 4-5 | Annie | Levels 4-5 flip to you as Tibbers' proximity starts threatening lethal punishes on overextension. |
| Level 6 | Annie | Level 6 is your peak — Tibbers all-in overwhelms Karma's lack of hard CC or burst answer. |
| First item | Annie | First item favors you as your burst damage output outclasses anything her shields can absorb. |
| Two+ items | Annie | 2+ items remains yours since Karma has no scaling all-in tools to threaten your damage lead. |
Levels 1-2 already favor Karma hard — her Mantra-boosted Q deals big early poke and cooldown resets let her spam it far more often than you can safely approach, chipping your HP without giving you a stun opportunity. This stays true through levels 3-5: her range and shield sustain let her out-poke your melee-range trades, and without Tibbers you simply don't have the tools to punish her for staying at range. Expect to lose CS and take chip damage through this stretch unless you can predict and stun a greedy Karma push.
The full Annie vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karma vs Annie guide →
All Annie mid lane matchups →