The champions that counter Karma hardest in mid lane are Pantheon (44.02%), Neeko (44.78%) and Annie (45.16%) — those are Karma's own pooled win rates. The easiest matchups are Azir (53.98%), Mel (52.75%) and Ziggs (50.84%).
46 researched matchup guides for Karma in mid lane, most-played first. Win rates are Karma's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Karma vs Viktor | 47.78% | 8,515 | Leans Viktor |
| Karma vs Ahri | 46.85% | 7,847 | Leans Ahri |
| Karma vs Sylas | 47.2% | 7,678 | Leans Sylas |
| Karma vs Yasuo | 49.02% | 7,540 | Leans Yasuo |
| Karma vs Syndra | 47.06% | 7,366 | Leans Syndra |
| Karma vs Zed | 48.2% | 6,884 | Leans Zed |
| Karma vs Yone | 50.48% | 5,826 | Even |
| Karma vs Katarina | 45.46% | 5,730 | Leans Katarina |
| Karma vs Malzahar | 48.48% | 5,163 | Leans Malzahar |
| Karma vs Akali | 48.04% | 5,021 | Leans Akali |
| Karma vs Twisted Fate | 45.77% | 4,935 | Leans Twisted Fate |
| Karma vs Lissandra | 47.74% | 4,772 | Leans Lissandra |
| Karma vs Xerath | 47.35% | 4,581 | Leans Xerath |
| Karma vs Fizz | 46.93% | 4,409 | Leans Fizz |
| Karma vs Vladimir | 48.19% | 4,262 | Leans Vladimir |
| Karma vs Hwei | 47.24% | 4,135 | Leans Hwei |
| Karma vs LeBlanc | 46.78% | 4,132 | Leans LeBlanc |
| Karma vs Galio | 48.54% | 3,982 | Leans Galio |
| Karma vs Diana | 45.54% | 3,981 | Leans Diana |
| Karma vs Lux | 47.15% | 3,819 | Leans Lux |
| Karma vs Ryze | 49.81% | 2,943 | Even |
| Karma vs Veigar | 49.42% | 2,762 | Even |
| Karma vs Orianna | 49.8% | 2,745 | Even |
| Karma vs Akshan | 46.85% | 2,696 | Leans Akshan |
| Karma vs Zoe | 46.37% | 2,694 | Leans Zoe |
| Karma vs Vex | 46.45% | 2,680 | Leans Vex |
| Karma vs Mel | 52.75% | 2,612 | Leans Karma |
| Karma vs Ekko | 46.46% | 2,598 | Leans Ekko |
| Karma vs Irelia | 47.89% | 2,554 | Leans Irelia |
| Karma vs Kassadin | 47.11% | 2,488 | Leans Kassadin |
| Karma vs Naafiri | 48.59% | 2,206 | Leans Naafiri |
| Karma vs Aurora | 48.04% | 2,194 | Leans Aurora |
| Karma vs Anivia | 45.56% | 2,186 | Leans Anivia |
| Karma vs Talon | 47.84% | 2,172 | Leans Talon |
| Karma vs Qiyana | 47.93% | 2,151 | Leans Qiyana |
| Karma vs Annie | 45.16% | 1,962 | Leans Annie |
| Karma vs Cassiopeia | 49.25% | 1,326 | Leans Cassiopeia |
| Karma vs Taliyah | 48.93% | 1,263 | Leans Taliyah |
| Karma vs Aurelion Sol | 49.19% | 1,173 | Leans Aurelion Sol |
| Karma vs Azir | 53.98% | 1,145 | Leans Karma |
| Karma vs Pantheon | 44.02% | 827 | Pantheon favoured |
| Karma vs Brand | 47.17% | 814 | Leans Brand |
| Karma vs Ziggs | 50.84% | 710 | Leans Karma |
| Karma vs Swain | 48.61% | 681 | Leans Swain |
| Karma vs Neeko | 44.78% | 355 | Neeko favoured |
| Karma vs Locke | — | — | — |