Karma vs Lissandra — Mid Lane Matchup Guide

How to win lane as Karma against Lissandra · 39.56% win rate over 91 Emerald+ games · Updated 2026-07-27

Verdict: Closer than it looks — Karma owns 5 of the 7 game windows to Lissandra's 1, but the win rate still favours Lissandra: you have to convert those windows or the game slips away. Karma wins 39.56% of games vs Lissandra in mid lane (91 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1KarmaLevel 1 favors you since Lissandra's Q poke is short-range and easily avoided.
Level 2KarmaLevel 2 stays yours as she still lacks pressure to punish your zoning.
Level 3KarmaLevel 3 remains your favor with continued safe poke trades from range.
Levels 4-5Even / skillLevel 4 is an even skill check as both sides start weaving in more poke.
Level 6KarmaLevel 5 swings back to you before her ultimate engage threat comes online.
First itemLissandraFrozen Tomb at level 6 gives Lissandra a hard lockdown that wins her the trade.
Two+ itemsKarmaKarma's poke and Mantra utility retake control once past her ult window.

Early game (levels 1–5)

Levels 1-3 and levels 5 onward you control the lane — Lissandra's short-range Q poke and lack of sustained pressure mean Inner Flame and Focused Resolve win most trades, though level 4 is a closer skill check as she starts weaving in more poke with levels.

Read the rest of this matchup

The full Karma vs Lissandra report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Lissandra vs Karma guide →
All Karma mid lane matchups →