How to win lane as Lissandra against Karma · 52.1% win rate over 4,681 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Karma's RQ poke and shield out-trade you at level 1, so the edge is hers. |
| Level 2 | Karma | At 2 her empowered Mantra still gives her the stronger poke pattern. |
| Level 3 | Even / skill | By 3 her Mantra advantage evens out and it becomes a skill-based poke lane. |
| Levels 4-5 | Even / skill | Through 4-5 neither has a decisive edge before your ultimate arrives. |
| Level 6 | Lissandra | Frozen Tomb is a hard lock her shields can't answer, so 6 is yours. |
| First item | Lissandra | With first-item CDR you all-in through her shield once Mantra is down. |
| Two+ items | Lissandra | Late, your point-and-click CC out-teamfights her single-target utility. |
Karma owns levels 1-2: her RQ empowered bolt out-ranges and out-trades your Q, and her shield negates your poke, so give ground, farm safely, and don't contest until her Mantra is spent.
The full Lissandra vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karma vs Lissandra guide →
All Lissandra mid lane matchups →