Annie vs Qiyana — Mid Lane Matchup Guide

How to win lane as Annie against Qiyana · 53.95% win rate over 658 Emerald+ games · Updated 2026-07-27

Verdict: Annie is favoured — Annie owns 4 of the 7 game windows to Qiyana's 1. Annie wins 53.95% of games vs Qiyana in mid lane (658 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1AnnieLevel 1 favors you because Disintegrate punishes her early trades before she has W procs to escape or all-in with
Level 2Even / skillLevel 2 is a skill check — both champs are still setting up combos and neither has a clean kill threshold yet
Level 3Even / skillLevel 3 stays even as she starts weaving terrain procs but you can still poke her off approach with Incinerate
Levels 4-5AnnieLevel 4-5 favors you since Passive stun plus Tibbers is now lethal on her squishy HP before she gets a full rotation off
Level 6AnnieLevel 6 favors Qiyana because her ultimate's flash-dash lets her jump onto you exactly when your stun is down
First itemQiyanaFirst item favors you as Luden's/Mask burst plus a pre-placed stun kills her before she reaches her combo range
Two+ itemsAnnie2+ items favors you because your point-and-click one-shot combo is simply higher-ceiling burst than her terrain combo at equal gold

Early game (levels 1–5)

Levels 1-2 are close to even skill checks where whoever lands Disintegrate or an elemental auto first gets the tempo, then Qiyana can start looking for real trades level 3 onward as she picks up W and unlocks rock/grass procs, but she has to walk through your poke zone to reach you so it's still a skill matchup rather than a clean favor either way.

Read the rest of this matchup

The full Annie vs Qiyana report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Qiyana vs Annie guide →
All Annie mid lane matchups →