The champions that counter Qiyana hardest in mid lane are Diana (45.25%), Xerath (46.05%) and Twisted Fate (46.13%) — those are Qiyana's own pooled win rates. The easiest matchups are Aurelion Sol (57.21%), Azir (55.92%) and Neeko (52.9%).
46 researched matchup guides for Qiyana in mid lane, most-played first. Win rates are Qiyana's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Qiyana vs Sylas | 47.66% | 5,338 | Leans Sylas |
| Qiyana vs Ahri | 50.33% | 5,144 | Even |
| Qiyana vs Zed | 50.79% | 4,822 | Leans Qiyana |
| Qiyana vs Viktor | 49.1% | 4,528 | Leans Viktor |
| Qiyana vs Yasuo | 49.14% | 4,377 | Leans Yasuo |
| Qiyana vs Syndra | 48.7% | 4,343 | Leans Syndra |
| Qiyana vs Katarina | 46.63% | 4,295 | Leans Katarina |
| Qiyana vs Akali | 51.28% | 3,752 | Leans Qiyana |
| Qiyana vs Yone | 50.36% | 3,650 | Even |
| Qiyana vs Lissandra | 48.11% | 3,207 | Leans Lissandra |
| Qiyana vs Malzahar | 48.19% | 3,036 | Leans Malzahar |
| Qiyana vs Twisted Fate | 46.13% | 3,026 | Leans Twisted Fate |
| Qiyana vs Lux | 50.16% | 3,022 | Even |
| Qiyana vs Fizz | 46.84% | 2,974 | Leans Fizz |
| Qiyana vs Naafiri | 51.32% | 2,773 | Leans Qiyana |
| Qiyana vs Vladimir | 47.63% | 2,742 | Leans Vladimir |
| Qiyana vs Diana | 45.25% | 2,696 | Leans Diana |
| Qiyana vs LeBlanc | 47.83% | 2,599 | Leans LeBlanc |
| Qiyana vs Xerath | 46.05% | 2,467 | Leans Xerath |
| Qiyana vs Hwei | 51.02% | 2,403 | Leans Qiyana |
| Qiyana vs Talon | 48.29% | 2,270 | Leans Talon |
| Qiyana vs Karma | 52.07% | 2,151 | Leans Qiyana |
| Qiyana vs Galio | 49.15% | 2,122 | Leans Galio |
| Qiyana vs Ekko | 48.1% | 1,994 | Leans Ekko |
| Qiyana vs Irelia | 48.79% | 1,951 | Leans Irelia |
| Qiyana vs Vex | 46.48% | 1,934 | Leans Vex |
| Qiyana vs Akshan | 49.01% | 1,916 | Leans Akshan |
| Qiyana vs Mel | 51.26% | 1,904 | Leans Qiyana |
| Qiyana vs Ryze | 52.5% | 1,724 | Leans Qiyana |
| Qiyana vs Kassadin | 46.77% | 1,642 | Leans Kassadin |
| Qiyana vs Veigar | 50.44% | 1,600 | Even |
| Qiyana vs Zoe | 47.4% | 1,576 | Leans Zoe |
| Qiyana vs Orianna | 51.31% | 1,571 | Leans Qiyana |
| Qiyana vs Aurora | 48.98% | 1,474 | Leans Aurora |
| Qiyana vs Ziggs | 49.25% | 1,332 | Leans Ziggs |
| Qiyana vs Anivia | 51.21% | 1,287 | Leans Qiyana |
| Qiyana vs Annie | 49.16% | 1,184 | Leans Annie |
| Qiyana vs Pantheon | 49.78% | 1,137 | Even |
| Qiyana vs Brand | 50% | 948 | Even |
| Qiyana vs Swain | 51.14% | 831 | Leans Qiyana |
| Qiyana vs Taliyah | 51.23% | 816 | Leans Qiyana |
| Qiyana vs Cassiopeia | 52.46% | 732 | Leans Qiyana |
| Qiyana vs Aurelion Sol | 57.21% | 645 | Qiyana favoured |
| Qiyana vs Azir | 55.92% | 608 | Qiyana favoured |
| Qiyana vs Neeko | 52.9% | 535 | Leans Qiyana |
| Qiyana vs Locke | — | — | — |