Qiyana vs Karma — Mid Lane Matchup Guide

How to win lane as Qiyana against Karma · 52.22% win rate over 2,093 Emerald+ games · Updated 2026-07-27

Verdict: Qiyana is favoured — Qiyana owns 5 of the 7 game windows to Karma's 2. Qiyana wins 52.22% of games vs Karma in mid lane (2,093 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1KarmaKarma out-pokes you at level 1 with Inner Flame range.
Level 2KarmaAt 2 her Q poke keeps chunking you before your kit is online.
Level 3QiyanaLevel 3 gives you all elements to out-trade her point-blank.
Levels 4-5QiyanaLevels 4-5 you dodge her long-cooldown Q and punish it.
Level 6QiyanaYour level 6 flank burst beats her shield and Renewal heal.
First itemQiyanaFirst-item Qiyana one-combos her through a down shield.
Two+ itemsQiyanaYou stay the kill threat, only respecting her Mantra windows.

Early game (levels 1–5)

Karma out-pokes you at levels 1-2 with Inner Flame and, on level 3, a Mantra-empowered RQ that can chunk you before you even have your kit online. Play for CS, respect her range, and do not walk into her Q or you hand her the early lead the chart shows.

Read the rest of this matchup

The full Qiyana vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Playing the other side? Karma vs Qiyana guide →
All Qiyana mid lane matchups →