Qiyana vs Karma — Mid Lane Matchup Guide

How to win lane as Qiyana against Karma · 52.07% win rate (2,151 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15

Verdict: Qiyana is slightly favoured — 52.07% win rate over 2,151 games.

At a glance

Her combo wants open ground — fight her in elements: stealth breaks her aim, ice breaks her spacing, rock breaks her health bar.

Track: Karma's W — Focused Resolve (12s cooldown). The root tether — break it with range or line of sight.

Do

  • Trade from stealth angles only
  • E-string her post-combo silence
  • R the all-in she forces near walls

Don't

  • Stand in open lane trading combos
  • E in while her setup is loaded
  • Waste rock executes on full bars

Runes & build vs Karma

Start
Doran's Blade + Health Potion
First back
Serrated Dirk (≈1100g) — strings start chunking
First item
Eclipse / Profane Hydra
Then
Serylda's path
Boots
Mercury's Treads / Lucidity
Runes
Electrocute (Domination): Sudden Impact, Grisly Mementos, Relentless Hunter · Precision: Presence of Mind, Coup de Grace · Shards: Adaptive Force, Adaptive Force, Health

Favour timeline — the windows in Qiyana's game plan

Read from Qiyana's seat: which stage windows this plan plays for against Karma.

StageFavouredWhy
Level 1KarmaKarma out-pokes you at level 1 with Inner Flame range.
Level 2KarmaAt 2 her Q poke keeps chunking you before your kit is online.
Level 3Even / skillLevel 3 gives you all elements to out-trade her point-blank.
Levels 4-5Even / skillLevels 4-5 you dodge her long-cooldown Q and punish it.
Level 6QiyanaYour level 6 flank burst beats her shield and Renewal heal.
First itemQiyanaFirst-item Qiyana one-combos her through a down shield.
Two+ itemsEven / skillYou stay the kill threat, only respecting her Mantra windows.

How to beat Karma as Qiyana: the early game

Karma out-pokes you at levels 1-2 with Inner Flame and, on level 3, a Mantra-empowered RQ that can chunk you before you even have your kit online. Play for CS, respect her range, and do not walk into her Q or you hand her the early lead the chart shows. Track Karma Focused Resolve (W): 12s flat — walk the tether beyond its 675 range before the root lands; it governs your steps.

Hardest and easiest matchups for Qiyana in mid lane

Pooled Emerald+ win rates from Qiyana's side, sampled July 2026.

Hardest

Easiest

Read the rest of this matchup

The full Qiyana vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Common questions

Who wins Qiyana vs Karma in mid lane?

Qiyana, slightly — a 52.07% win rate edge over 2,151 games; execution can flip it.

Is Qiyana vs Karma a skill matchup?

Mostly — Qiyana has a small statistical edge (52.07% win rate), but execution decides this lane far more than the pick does.

Does Qiyana counter Karma?

Not a hard counter — Qiyana has a slight edge (52.07% win rate), and play quality decides the rest.

What runes does Qiyana take vs Karma?

Qiyana takes Electrocute on the Domination tree with Sudden Impact, Grisly Mementos and Relentless Hunter, and Precision secondary (Presence of Mind and Coup de Grace) vs Karma.

What should Qiyana build vs Karma?

Start Doran's Blade + Health Potion and back for Serrated Dirk (≈1100g) — strings start chunking. Build Eclipse / Profane Hydra first, then Serylda's path, with Mercury's Treads / Lucidity.

Related guides

Playing the other side? Karma vs Qiyana guide →
All Qiyana mid lane matchups →

More Qiyana mid lane matchups: vs Galio · vs Hwei · vs Irelia · vs Kassadin · vs Katarina · vs LeBlanc