How to win lane as Annie against Syndra · 49.24% win rate over 2,250 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Syndra | Level 1 favors Syndra since her Dark Sphere already out-ranges your poke before you have any combo pieces |
| Level 2 | Syndra | Level 2 favors Syndra as she continues to zone you safely while you have no stun threat yet |
| Level 3 | Syndra | Level 3 favors Syndra because her stun-chain all-in is now online and you still can't punish the approach |
| Levels 4-5 | Syndra | Level 4-5 favors Syndra as her full combo damage output is highest right before level 6 while yours is still catching up |
| Level 6 | Annie | Level 6 favors you since your own Tibbers threat is now real enough to make her think twice about overextending |
| First item | Syndra | First item favors Syndra because her poke and burst damage per item are still ahead of your early spike |
| Two+ items | Annie | 2+ items favors you as your guaranteed stun-into-Tibbers combo punishes her positioning faster than her setup-dependent combo can react |
Levels 1-5 are rough for you because Syndra out-ranges Disintegrate with Dark Sphere, and her Scatter the Weak stun-chain punishes any approach, so you should prioritize safe farming and roaming over lane trades in this stretch, especially once she's fully leveled her combo by 5.
The full Annie vs Syndra report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Syndra vs Annie guide →
All Annie mid lane matchups →