The champions that counter Syndra hardest in mid lane are Fizz (45.96%), Katarina (46.47%) and Xerath (47.48%) — those are Syndra's own pooled win rates. The easiest matchups are Ryze (56.28%), Mel (56.22%) and Cassiopeia (56.1%).
46 researched matchup guides for Syndra in mid lane, most-played first. Win rates are Syndra's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Syndra vs Viktor | 51.29% | 26,795 | Leans Syndra |
| Syndra vs Ahri | 50.13% | 19,795 | Even |
| Syndra vs Sylas | 49.06% | 15,176 | Leans Sylas |
| Syndra vs Xerath | 47.48% | 14,134 | Leans Xerath |
| Syndra vs Fizz | 45.96% | 12,993 | Leans Fizz |
| Syndra vs Yasuo | 50.59% | 12,312 | Even |
| Syndra vs Yone | 53.39% | 12,016 | Leans Syndra |
| Syndra vs Zed | 47.95% | 11,731 | Leans Zed |
| Syndra vs Katarina | 46.47% | 11,539 | Leans Katarina |
| Syndra vs Hwei | 51.17% | 11,003 | Leans Syndra |
| Syndra vs Lux | 51.59% | 10,940 | Leans Syndra |
| Syndra vs Malzahar | 51.58% | 10,302 | Leans Syndra |
| Syndra vs Twisted Fate | 50.37% | 9,809 | Even |
| Syndra vs Lissandra | 51.46% | 9,797 | Leans Syndra |
| Syndra vs Naafiri | 51.37% | 9,183 | Leans Syndra |
| Syndra vs Akali | 52.63% | 9,100 | Leans Syndra |
| Syndra vs Vladimir | 50.03% | 8,863 | Even |
| Syndra vs Orianna | 55.75% | 8,081 | Syndra favoured |
| Syndra vs Diana | 48.7% | 7,630 | Leans Diana |
| Syndra vs LeBlanc | 51.38% | 7,607 | Leans Syndra |
| Syndra vs Karma | 52.94% | 7,366 | Leans Syndra |
| Syndra vs Galio | 52.86% | 7,319 | Leans Syndra |
| Syndra vs Mel | 56.22% | 7,227 | Syndra favoured |
| Syndra vs Ryze | 56.28% | 6,718 | Syndra favoured |
| Syndra vs Veigar | 51.04% | 6,634 | Leans Syndra |
| Syndra vs Talon | 51.66% | 6,426 | Leans Syndra |
| Syndra vs Akshan | 50.82% | 6,315 | Leans Syndra |
| Syndra vs Ekko | 48.33% | 6,247 | Leans Ekko |
| Syndra vs Irelia | 49.4% | 5,903 | Even |
| Syndra vs Zoe | 48.33% | 5,794 | Leans Zoe |
| Syndra vs Vex | 52.21% | 5,627 | Leans Syndra |
| Syndra vs Aurora | 51.68% | 5,478 | Leans Syndra |
| Syndra vs Kassadin | 50.69% | 4,976 | Even |
| Syndra vs Anivia | 52.54% | 4,962 | Leans Syndra |
| Syndra vs Ziggs | 48.27% | 4,951 | Leans Ziggs |
| Syndra vs Annie | 52.07% | 4,778 | Leans Syndra |
| Syndra vs Qiyana | 51.3% | 4,343 | Leans Syndra |
| Syndra vs Pantheon | 53.5% | 3,824 | Leans Syndra |
| Syndra vs Cassiopeia | 56.1% | 3,469 | Syndra favoured |
| Syndra vs Brand | 53.28% | 3,221 | Leans Syndra |
| Syndra vs Swain | 54.34% | 3,123 | Leans Syndra |
| Syndra vs Taliyah | 54.76% | 3,092 | Leans Syndra |
| Syndra vs Aurelion Sol | 49.94% | 2,719 | Even |
| Syndra vs Azir | 55.88% | 2,602 | Syndra favoured |
| Syndra vs Neeko | 52.09% | 2,079 | Leans Syndra |
| Syndra vs Locke | — | — | — |