Lissandra vs Vladimir — Mid Lane Matchup Guide

How to win lane as Lissandra against Vladimir · 51.08% win rate over 2,837 Emerald+ games · Updated 2026-07-27

Verdict: Lissandra is favoured — Lissandra owns 5 of the 7 game windows. Lissandra wins 51.08% of games vs Vladimir in mid lane (2,837 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1LissandraLevel 1 is clearly yours — Vladimir is a famously weak, mana-starved early laner your Q abuses.
Level 2Even / skillAt level 2 his Pool lets him negate your combo, making trades skill-based.
Level 3Even / skillLevel 3 stays even as the all-in becomes a Pool-cooldown timing game.
Levels 4-5LissandraBy levels 4-5 you bait the Pool and all-in him before he can heal through it.
Level 6LissandraYour level 6 R hard-locks a Pool-cooldown Vladimir and denies his Hemoplague value.
First itemLissandraOn first item you dive and Tomb him under tower before his health curve kicks in.
Two+ itemsLissandraIn 2+ item fights your engage and peel shut down his dive despite his scaling.

Early game (levels 1–5)

Level 1 is clearly yours — Vladimir is one of the weakest early laners in the game, low base damage and mana-starved, while your Q pokes him for free. Levels 2-3 skill out around his Pool: if you dump your combo he can Sanguine Pool the stun and negate it, so the trade becomes about timing his cooldown, not raw stats.

Read the rest of this matchup

The full Lissandra vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Vladimir vs Lissandra guide →
All Lissandra mid lane matchups →