Lissandra vs Vex — Mid Lane Matchup Guide

How to win lane as Lissandra against Vex · 51.98% win rate over 1,337 Emerald+ games · Updated 2026-07-27

Verdict: Lissandra is favoured — Lissandra owns 2 of the 7 game windows to Vex's 1. Lissandra wins 51.98% of games vs Vex in mid lane (1,337 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1Even / skillLevel 1 is even — her Gloom-fear threat offsets your longer Q range.
Level 2Even / skillAt level 2 neither commits; her empowered Q interrupt trades with your poke.
Level 3Even / skillLevel 3 stays skill-based as her fear can cancel your E engage.
Levels 4-5Even / skillThrough levels 4-5 the fear-versus-dash mind game keeps trades even.
Level 6LissandraYour level 6 R is an uncancellable lock that beats her telegraphed Shadow Surge.
First itemLissandraOn first item you shove faster and your all-in out-damages her pre-item burst.
Two+ itemsVexIn 2+ item fights her resetting long-range R and burst out-scale your engage.

Early game (levels 1–5)

The early levels are a skill matchup read around her passive. Her Gloom mark turns her next Q into a fear that stops your E dash cold, so you can't just facecheck engage — poke with Q, force the empowered proc onto a minion, then trade. Neither of you wins level 1-4 outright; it's about who respects the other's cooldowns.

Read the rest of this matchup

The full Lissandra vs Vex report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Vex vs Lissandra guide →
All Lissandra mid lane matchups →