The champions that counter Vex hardest in mid lane are Annie (45.21%), Vladimir (47.02%) and Hwei (47.1%) — those are Vex's own pooled win rates. The easiest matchups are Azir (58.38%), Pantheon (57.28%) and LeBlanc (55.54%).
46 researched matchup guides for Vex in mid lane, most-played first. Win rates are Vex's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Vex vs Yasuo | 54.35% | 8,561 | Leans Vex |
| Vex vs Sylas | 54.47% | 7,539 | Leans Vex |
| Vex vs Ahri | 50.68% | 6,596 | Even |
| Vex vs LeBlanc | 55.54% | 6,102 | Vex favoured |
| Vex vs Katarina | 51.7% | 5,942 | Leans Vex |
| Vex vs Syndra | 47.79% | 5,627 | Leans Syndra |
| Vex vs Yone | 55.38% | 5,403 | Vex favoured |
| Vex vs Viktor | 47.68% | 5,357 | Leans Viktor |
| Vex vs Zed | 50.9% | 5,043 | Leans Vex |
| Vex vs Akali | 53.67% | 5,029 | Leans Vex |
| Vex vs Lux | 52.41% | 4,163 | Leans Vex |
| Vex vs Fizz | 50.7% | 3,862 | Even |
| Vex vs Naafiri | 53.04% | 3,763 | Leans Vex |
| Vex vs Xerath | 48.06% | 3,485 | Leans Xerath |
| Vex vs Malzahar | 51.62% | 3,359 | Leans Vex |
| Vex vs Vladimir | 47.02% | 3,222 | Leans Vladimir |
| Vex vs Diana | 51.97% | 3,121 | Leans Vex |
| Vex vs Twisted Fate | 47.95% | 3,099 | Leans Twisted Fate |
| Vex vs Hwei | 47.1% | 3,000 | Leans Hwei |
| Vex vs Akshan | 54% | 2,950 | Leans Vex |
| Vex vs Talon | 53.03% | 2,910 | Leans Vex |
| Vex vs Irelia | 53.14% | 2,881 | Leans Vex |
| Vex vs Karma | 53.55% | 2,680 | Leans Vex |
| Vex vs Lissandra | 49.82% | 2,668 | Even |
| Vex vs Ekko | 51.31% | 2,594 | Leans Vex |
| Vex vs Veigar | 48.81% | 2,391 | Leans Veigar |
| Vex vs Mel | 50.79% | 2,280 | Leans Vex |
| Vex vs Galio | 51.72% | 2,177 | Leans Vex |
| Vex vs Qiyana | 53.52% | 1,934 | Leans Vex |
| Vex vs Orianna | 52.55% | 1,842 | Leans Vex |
| Vex vs Ziggs | 51.4% | 1,823 | Leans Vex |
| Vex vs Zoe | 52.28% | 1,685 | Leans Vex |
| Vex vs Pantheon | 57.28% | 1,620 | Vex favoured |
| Vex vs Ryze | 52.5% | 1,596 | Leans Vex |
| Vex vs Aurora | 53.68% | 1,576 | Leans Vex |
| Vex vs Annie | 45.21% | 1,575 | Leans Annie |
| Vex vs Kassadin | 51.08% | 1,490 | Leans Vex |
| Vex vs Anivia | 48.15% | 1,483 | Leans Anivia |
| Vex vs Brand | 52.02% | 1,336 | Leans Vex |
| Vex vs Swain | 51.82% | 1,287 | Leans Vex |
| Vex vs Taliyah | 51.7% | 824 | Leans Vex |
| Vex vs Neeko | 52.25% | 798 | Leans Vex |
| Vex vs Cassiopeia | 54.2% | 786 | Leans Vex |
| Vex vs Azir | 58.38% | 776 | Vex favoured |
| Vex vs Aurelion Sol | 51.5% | 769 | Leans Vex |
| Vex vs Locke | — | — | — |