Vex vs Annie — Mid Lane Matchup Guide

How to win lane as Vex against Annie · 45.21% win rate (1,575 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15

Verdict: Annie is slightly favoured — Vex wins 45.21% of 1,575 games, and every window is a skill check.

At a glance

Her combo is a sprint through your fear field — mark the approach and her engage spell arrives pre-interrupted.

Track: Annie's R — Summon: Tibbers (130–100s cooldown). Flash-Tibbers off a stocked passive stun is her whole threat — watch the glow under her feet.

Do

  • E the space her combo needs
  • Hold W's pulse for the real commit
  • R the retreat below half

Don't

  • Trade while her setup spell is loaded
  • Fear-pulse her poke instead of her engage
  • Stand at her max range unmarked

Runes & build vs Annie

Start
Doran's Ring + 2 Health Potions
First back
Lost Chapter (≈1300g) — the gloom goes sustainable
First item
Luden's Companion
Then
Shadowflame
Boots
Sorcerer's Shoes / Mercury's Treads
Runes
Electrocute (Domination): Cheap Shot, Grisly Mementos, Ultimate Hunter · Sorcery: Manaflow Band, Transcendence · Shards: Adaptive Force, Adaptive Force, Health

Favour timeline — the windows in Vex's game plan

Read from Vex's seat: which stage windows this plan plays for against Annie.

StageFavouredWhy
Level 1Even / skillYou out-range her 625 point-and-click and farm safely at level 1.
Level 2Even / skillYour reach lets you poke at level 2 without entering her stun distance.
Level 3Even / skillE-Q chunks her from outside stun range through levels 3-5.
Levels 4-5Even / skillAt 4-5 the stun-tracking game favors your longer poke and W shield.
Level 6Even / skillShadow Surge lets you fear or disengage her level-6 flash-Tibbers all-in.
First itemEven / skillFirst-item your E-Q-W keeps her permanently outside stun range.
Two+ itemsEven / skillIn 2-item fights you kite from range her Tibbers and auto can't reach.

How to beat Annie as Vex: the early game

Levels 1-2 Annie can shove and look for an early stunned trade, so respect her Pyromania stacks and don't stand in W-Incinerate range when she's charged. Farm at max range and use your reach to poke when her stun is not up. Keep the wave neutral so she can't set up a level-6 dive with jungle help. Track Summon: Tibbers is 130s at rank 1 — flash-Tibbers off a stocked Pyromania stun is her whole threat; watch the glow under her feet and step up on its downtime.

Hardest and easiest matchups for Vex in mid lane

Pooled Emerald+ win rates from Vex's side, sampled July 2026.

Hardest

Easiest

Read the rest of this matchup

The full Vex vs Annie report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Common questions

Who wins Vex vs Annie in mid lane?

Annie, slightly — Vex wins 45.21% of 1,575 games; winnable with the right plan.

Is Vex vs Annie a skill matchup?

Mostly — Annie has a small statistical edge (54.79% win rate), but execution decides this lane far more than the pick does.

Does Vex counter Annie?

No — if anything Annie has the slight edge (Vex wins 45.21%), though it stays close.

What runes does Vex take vs Annie?

Vex takes Electrocute on the Domination tree with Cheap Shot, Grisly Mementos and Ultimate Hunter, and Sorcery secondary (Manaflow Band and Transcendence) vs Annie.

What should Vex build vs Annie?

Start Doran's Ring + 2 Health Potions and back for Lost Chapter (≈1300g) — the gloom goes sustainable. Build Luden's Companion first, then Shadowflame, with Sorcerer's Shoes / Mercury's Treads.

Related guides

Playing the other side? Annie vs Vex guide →
All Vex mid lane matchups →

More Vex mid lane matchups: vs Akali · vs Akshan · vs Anivia · vs Aurelion Sol · vs Aurora · vs Azir