How to win lane as Vex against Karma · 53.61% win rate over 2,634 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Karma's RQ root out-ranges and out-pokes you at level 1 with her ult available. |
| Level 2 | Karma | At level 2 her Mantra poke and shield keep the sustained trade in her favor. |
| Level 3 | Karma | Through level 3 she still wins the poke war before your burst combo comes online. |
| Levels 4-5 | Vex | At level 4 your W+Q spike arrives and Karma's lack of a dash lets you punish her cooldowns. |
| Level 6 | Vex | Level 6 R Shadow Surge gives you an engage she can't escape without a blink. |
| First item | Vex | First item your Luden's burst breaks her E shield in a single rotation. |
| Two+ items | Vex | With two items you out-damage her sustain and R catches her every time. |
Levels 1-3 are Karma's: her RQ (Mantra-empowered Q) roots and detonates for heavy poke, and she can start with her ult so she out-ranges and out-sustains you immediately. Don't try to trade into a full Mantra window. Soak XP, dodge the Q, and track her Mantra cooldown so you know when she's vulnerable.
The full Vex vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karma vs Vex guide →
All Vex mid lane matchups →