Lissandra vs Locke — Mid Lane Matchup Guide

How to win lane as Lissandra against Locke · Matchup data reviewed on patch 26.15

Verdict: A genuine skill matchup — every window is a skill check.

At a glance

You are the assassin's nightmare pick — root the dash, tomb the dive, and counter-kill the reset he no longer has.

Track: Locke's Q — Ritual Nails (10–6s cooldown). The nail marks are his whole engine — without 2-3 stacks on you his blink-in barely dents; sidestep the recasts and punish the ten seconds of nothing.

Do

  • Stand close enough to invite the dive
  • Self-R his burst, then W-Q the counter
  • Claw out the moment the exchange sours

Don't

  • Hold W so long the dash already landed
  • Waste the tomb on poke-level damage
  • Chase resets past your claw range

Runes & build vs Locke

Start
Doran's Ring + 2 Health Potions
First back
Oblivion Orb (≈800g) — cuts his sustain
First item
Malignance
Then
Zhonya's Hourglass
Boots
Sorcerer's Shoes / Mercury's Treads
Runes
Electrocute (Domination): Cheap Shot, Grisly Mementos, Ultimate Hunter · Sorcery: Manaflow Band, Transcendence · Shards: Adaptive Force, Adaptive Force, Health

Favour timeline — the windows in Lissandra's game plan

Read from Lissandra's seat: which stage windows this plan plays for against Locke.

StageFavouredWhy
Level 1Even / skillNo data available, so level 1 is treated as an even skill lane.
Level 2Even / skillLevel 2 defaults to skill-based with no known edge either way.
Level 3Even / skillThrough 3 it stays even pending real matchup information.
Levels 4-5Even / skillAt 4-5 it remains a skill-check with no established favourite.
Level 6Even / skillEven at 6 it's marked even, though your reliable R is a dependable swing.
First itemEven / skillFirst item stays skill-based absent data on his spikes.
Two+ itemsEven / skillLate is even on record, with your teamfight CC as your baseline strength.

How to beat Locke as Lissandra: the early game

No games on record, so treat this as an even, skill-based lane — win it on fundamentals: control the wave with Q, respect the unknown, and don't over-extend without vision or a clear cooldown read. Track Locke Ritual Nails (Marks): matchup-defining — The nail marks are his whole engine — without 2-3 stacks on you his blink-in barely dents; sidestep the recasts and punish the ten seconds of nothing. Track it before every step-up.

Hardest and easiest matchups for Lissandra in mid lane

Pooled Emerald+ win rates from Lissandra's side, sampled July 2026.

Hardest

Easiest

Read the rest of this matchup

The full Lissandra vs Locke report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

Read the full guide — plans from $1.99/month →

🔒 Secure checkout · 💰 7-day money-back guarantee on your first payment · ✋ Cancel anytime
Lane Pass $1.99/mo · All Lanes $3.99/mo · Annual $24.99/yr. Renews automatically — cancel anytime.

Common questions

Who wins Lissandra vs Locke in mid lane?

No sample yet — Lissandra vs Locke has no Emerald+ win-rate data for this patch; treat it as a skill matchup and play the plan below.

Is Lissandra vs Locke a skill matchup?

Yes — every one of the 7 stage windows in Lissandra vs Locke is a skill check.

What runes does Lissandra take vs Locke?

Lissandra takes Electrocute on the Domination tree with Cheap Shot, Grisly Mementos and Ultimate Hunter, and Sorcery secondary (Manaflow Band and Transcendence) vs Locke.

What should Lissandra build vs Locke?

Start Doran's Ring + 2 Health Potions and back for Oblivion Orb (≈800g) — cuts his sustain. Build Malignance first, then Zhonya's Hourglass, with Sorcerer's Shoes / Mercury's Treads.

Related guides

Playing the other side? Locke vs Lissandra guide →
All Lissandra mid lane matchups →

More Lissandra mid lane matchups: vs Kassadin · vs Katarina · vs LeBlanc · vs Lux · vs Malzahar · vs Mel