How to win lane as Lissandra against Cassiopeia · 52.27% win rate over 815 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is a skill check over dodging her Noxious Blast poke. |
| Level 2 | Even / skill | Level 2 stays even as both trade on cooldowns and positioning. |
| Level 3 | Even / skill | Level 3 remains skill-dependent around her Q hits and your E dodges. |
| Levels 4-5 | Cassiopeia | At levels 4-5 Cassiopeia's Miasma zoning and Twin Fang DPS out-sustain you, favouring her. |
| Level 6 | Lissandra | At 6 your point-and-click R beats her facing-dependent Petrifying Gaze, favouring you. |
| First item | Cassiopeia | On her first item Cassiopeia's kite and slow-ramp burst edge the trades back to her. |
| Two+ items | Lissandra | At 2-plus items your reliable lockdown and dive out-scale her immobile body. |
Levels 1-3 are pure skill: dodge her Q Noxious Blast to deny her movement speed and she can't chunk you, but eat it and she snowballs the trade.
The full Lissandra vs Cassiopeia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Cassiopeia vs Lissandra guide →
All Lissandra mid lane matchups →