Lissandra vs Syndra — Mid Lane Matchup Guide

How to win lane as Lissandra against Syndra · 50.07% win rate over 4,911 Emerald+ games · Updated 2026-07-27

Verdict: Lissandra is favoured — Lissandra owns 3 of the 7 game windows. Lissandra wins 50.07% of games vs Syndra in mid lane (4,911 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1Even / skillLevel 1 is even skill as neither has an all-in and it's a farm-and-poke lane.
Level 2Even / skillLevel 2 stays skill: her range advantage is offset by your safe Q wave control.
Level 3Even / skillLevel 3 remains a coin-flip where her E-stun setup and your E disengage cancel out.
Levels 4-5Even / skillLevels 4-5 are still skill since you can dodge her combo while she respects your gap-close.
Level 6LissandraLevel 6 favours Lissandra because Frozen Tomb is unmissable against her skillshot-reliant burst.
First itemLissandraAt first item your guaranteed CC chain locks her before she can combo, so the spike is yours.
Two+ itemsLissandraWith two-plus items your reliable AoE R catches her before her ult window opens, keeping fights yours.

Early game (levels 1–5)

Levels 1-4 are a skill matchup. Syndra out-ranges you and can poke with Q and QE, so respect her sphere-stun setup: use your own Q to farm safely, sidestep her E line, and only think about E-engaging when her stun is down. Play the CS game and don't feed her the free poke that snowballs her spheres.

Read the rest of this matchup

The full Lissandra vs Syndra report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Syndra vs Lissandra guide →
All Lissandra mid lane matchups →