Lissandra vs Sylas — Mid Lane Matchup Guide

How to win lane as Lissandra against Sylas · 50.33% win rate over 5,933 Emerald+ games · Updated 2026-07-27

Verdict: Lissandra is favoured — Lissandra owns 6 of the 7 game windows to Sylas's 1. Lissandra wins 50.33% of games vs Sylas in mid lane (5,933 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1LissandraLevel 1 favours Lissandra because Sylas is melee and can't reach you without committing an E dash.
Level 2LissandraLevel 2 stays yours as you punish his approach with Q before his heal ramps.
Level 3LissandraLevel 3 is Lissandra's since his empty E windows let you E-W all-in.
Levels 4-5LissandraLevels 4-5 remain yours because your W cuts his W-Q sustain chain.
Level 6LissandraLevel 6 is still Lissandra-favoured as you hold the all-in advantage while playing around his Hijack.
First itemLissandraAt first item your burst and root deny his healing, keeping the edge yours.
Two+ itemsSylasWith two-plus items Sylas out-scales you — bruiser sustain plus the ability to Hijack your ult flips fights.

Early game (levels 1–5)

Levels 1-5 are all yours. Sylas is melee and forced to E-dash into your range to do anything, so you Q him on the approach and punish every empty E window with a full E-W-Q all-in. Your point-and-click W interrupts his W-Q sustain chain, so his trades never heal the way he needs while you hold the wave and lane tempo.

Read the rest of this matchup

The full Lissandra vs Sylas report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Sylas vs Lissandra guide →
All Lissandra mid lane matchups →