The champions that counter Yasuo hardest in mid lane are Vladimir (44%), Lissandra (44.58%) and Aurelion Sol (45.12%) — those are Yasuo's own pooled win rates. The easiest matchups are Akshan (53.72%), Mel (52.51%) and Lux (52.51%).
46 researched matchup guides for Yasuo in mid lane, most-played first. Win rates are Yasuo's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Yasuo vs Zed | 48.72% | 16,962 | Leans Zed |
| Yasuo vs Yone | 46.95% | 16,917 | Leans Yone |
| Yasuo vs Sylas | 50.66% | 16,679 | Even |
| Yasuo vs Ahri | 49.09% | 15,858 | Leans Ahri |
| Yasuo vs Viktor | 45.42% | 14,983 | Leans Viktor |
| Yasuo vs Lissandra | 44.58% | 14,384 | Lissandra favoured |
| Yasuo vs Katarina | 50.68% | 13,290 | Even |
| Yasuo vs Akali | 49.64% | 13,259 | Even |
| Yasuo vs Syndra | 49.41% | 12,312 | Even |
| Yasuo vs Vladimir | 44% | 12,165 | Vladimir favoured |
| Yasuo vs Malzahar | 45.29% | 11,848 | Leans Malzahar |
| Yasuo vs Lux | 52.51% | 10,654 | Leans Yasuo |
| Yasuo vs Fizz | 48.06% | 9,613 | Leans Fizz |
| Yasuo vs Naafiri | 52.04% | 8,845 | Leans Yasuo |
| Yasuo vs Vex | 45.65% | 8,561 | Leans Vex |
| Yasuo vs Twisted Fate | 51.11% | 8,051 | Leans Yasuo |
| Yasuo vs Diana | 50.33% | 7,687 | Even |
| Yasuo vs Karma | 50.98% | 7,540 | Leans Yasuo |
| Yasuo vs Xerath | 48.59% | 7,504 | Leans Xerath |
| Yasuo vs Hwei | 49.24% | 7,326 | Leans Hwei |
| Yasuo vs LeBlanc | 49.43% | 7,059 | Even |
| Yasuo vs Talon | 49.48% | 6,762 | Even |
| Yasuo vs Mel | 52.51% | 6,545 | Leans Yasuo |
| Yasuo vs Irelia | 50.38% | 6,517 | Even |
| Yasuo vs Ekko | 49.88% | 6,269 | Even |
| Yasuo vs Galio | 47.82% | 6,202 | Leans Galio |
| Yasuo vs Kassadin | 48.08% | 5,531 | Leans Kassadin |
| Yasuo vs Veigar | 47.34% | 5,507 | Leans Veigar |
| Yasuo vs Ryze | 51.3% | 5,371 | Leans Yasuo |
| Yasuo vs Orianna | 51.38% | 5,253 | Leans Yasuo |
| Yasuo vs Akshan | 53.72% | 5,246 | Leans Yasuo |
| Yasuo vs Annie | 46.07% | 5,118 | Leans Annie |
| Yasuo vs Pantheon | 47.33% | 5,059 | Leans Pantheon |
| Yasuo vs Zoe | 50.05% | 5,009 | Even |
| Yasuo vs Ziggs | 47.26% | 4,670 | Leans Ziggs |
| Yasuo vs Qiyana | 50.86% | 4,377 | Leans Yasuo |
| Yasuo vs Anivia | 48.17% | 4,233 | Leans Anivia |
| Yasuo vs Aurora | 50.51% | 4,187 | Even |
| Yasuo vs Brand | 50.73% | 3,734 | Even |
| Yasuo vs Swain | 51.52% | 3,573 | Leans Yasuo |
| Yasuo vs Taliyah | 45.93% | 3,294 | Leans Taliyah |
| Yasuo vs Azir | 48.22% | 3,026 | Leans Azir |
| Yasuo vs Aurelion Sol | 45.12% | 2,753 | Leans Aurelion Sol |
| Yasuo vs Cassiopeia | 50.14% | 2,517 | Even |
| Yasuo vs Neeko | 48.62% | 1,915 | Leans Neeko |
| Yasuo vs Locke | — | — | — |