The champions that counter Vayne hardest in bot lane are Senna (45.99%), Aphelios (46.47%) and Nilah (46.62%) — those are Vayne's own pooled win rates. The easiest matchups are Corki (54.34%), Ezreal (53.67%) and Varus (53.28%).
29 researched matchup guides for Vayne in bot lane, most-played first. Win rates are Vayne's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Vayne vs Kai'Sa | 51.53% | 21,709 | Leans Vayne |
| Vayne vs Caitlyn | 48.48% | 20,365 | Leans Caitlyn |
| Vayne vs Jhin | 51.72% | 20,310 | Leans Vayne |
| Vayne vs Ezreal | 53.67% | 18,240 | Leans Vayne |
| Vayne vs Jinx | 47.81% | 16,850 | Leans Jinx |
| Vayne vs Ashe | 48.32% | 12,825 | Leans Ashe |
| Vayne vs Lucian | 50.12% | 10,368 | Even |
| Vayne vs Miss Fortune | 48.81% | 10,048 | Leans Miss Fortune |
| Vayne vs Senna | 45.99% | 9,708 | Leans Senna |
| Vayne vs Tristana | 48.27% | 9,662 | Leans Tristana |
| Vayne vs Seraphine | 49.63% | 8,697 | Even |
| Vayne vs Twitch | 48.62% | 8,448 | Leans Twitch |
| Vayne vs Smolder | 47.19% | 8,311 | Leans Smolder |
| Vayne vs Samira | 49.6% | 8,275 | Even |
| Vayne vs Aphelios | 46.47% | 6,773 | Leans Aphelios |
| Vayne vs Sivir | 52.34% | 6,194 | Leans Vayne |
| Vayne vs Draven | 48.25% | 5,678 | Leans Draven |
| Vayne vs Zeri | 50.05% | 5,099 | Even |
| Vayne vs Xayah | 47.23% | 5,069 | Leans Xayah |
| Vayne vs Ziggs | 52.93% | 4,506 | Leans Vayne |
| Vayne vs Varus | 53.28% | 3,699 | Leans Vayne |
| Vayne vs Veigar | 49.51% | 3,230 | Even |
| Vayne vs Swain | 52.71% | 2,916 | Leans Vayne |
| Vayne vs Kalista | 51.58% | 2,662 | Leans Vayne |
| Vayne vs Kog'Maw | 48.81% | 2,393 | Leans Kog'Maw |
| Vayne vs Nilah | 46.62% | 2,089 | Leans Nilah |
| Vayne vs Corki | 54.34% | 1,658 | Leans Vayne |
| Vayne vs Karthus | 51.07% | 1,216 | Leans Vayne |
| Vayne vs Heimerdinger | 49.54% | 969 | Even |