How to win lane as Vayne against Miss Fortune · 48.81% win rate (10,048 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Her tools tax your short range — farm the procs that are free and condemn the pick that eventually comes.
Track: Miss Fortune's R — Bullet Time (120–100s cooldown). The channel deletes grouped fights — spread, interrupt, and never clump in her cone.
Read from Vayne's seat: which stage windows this plan plays for against Miss Fortune.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is even in a farm-and-poke standoff with no all-in yet. |
| Level 2 | Even / skill | Level 2 stays skill-based as her Q poke is offset by your Tumble dodging. |
| Level 3 | Even / skill | Level 3 remains a coin-flip decided by whether you break her Double Up angles. |
| Levels 4-5 | Even / skill | Levels 4-5 stay even, with her poke balanced against your safe-scaling potential. |
| Level 6 | Miss Fortune | Level 6 favors Miss Fortune because Bullet Time plus support CC is a lane-ending all-in you can't yet answer. |
| First item | Miss Fortune | First item favors MF as her poke lead and ult threat peak before your scaling arrives. |
| Two+ items | Vayne | At 2+ items you win: the escape-less MF gets run down by Final Hour, Silver Bolts, and Condemn. |
Levels 1-3 are skill-based: MF's Double Up poke punishes sloppy CS, but if you Tumble to break minion bounce lines and only trade on her Q cooldown, you farm even. Break the bounce line with a Tumble rather than by standing still, and only trade when her Double Up is on cooldown. Land the three-hit pattern and leave. Keep Condemn for the moment she walks forward, because knocking her back into her own wave is what ends her poke rotation.
Pooled Emerald+ win rates from Vayne's side, sampled July 2026.
The full Vayne vs Miss Fortune report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Miss Fortune, slightly — Vayne wins 48.81% of 10,048 games; winnable with the right plan.
Mostly — Miss Fortune has a small statistical edge (51.19% win rate), but execution decides this lane far more than the pick does.
No — if anything Miss Fortune has the slight edge (Vayne wins 48.81%), though it stays close.
Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Bloodline and Coup de Grace, and Domination secondary (Taste of Blood and Treasure Hunter) vs Miss Fortune.
Start Doran's Blade + Health Potion and back for Cutlass / Recurve (≈1000g). Build Blade of the Ruined King first, then Guinsoo's / Terminus, with Plated Steelcaps / Berserker's.
Playing the other side? Miss Fortune vs Vayne guide →
All Vayne bot lane matchups →
More Vayne bot lane matchups: vs Karthus · vs Kog'Maw · vs Lucian · vs Nilah · vs Samira · vs Senna