How to win lane as Vayne against Miss Fortune · 51.58% win rate over 5,010 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is even in a farm-and-poke standoff with no all-in yet. |
| Level 2 | Even / skill | Level 2 stays skill-based as her Q poke is offset by your Tumble dodging. |
| Level 3 | Even / skill | Level 3 remains a coin-flip decided by whether you break her Double Up angles. |
| Levels 4-5 | Even / skill | Levels 4-5 stay even, with her poke balanced against your safe-scaling potential. |
| Level 6 | Miss Fortune | Level 6 favors Miss Fortune because Bullet Time plus support CC is a lane-ending all-in you can't yet answer. |
| First item | Miss Fortune | First item favors MF as her poke lead and ult threat peak before your scaling arrives. |
| Two+ items | Vayne | At 2+ items you win: the escape-less MF gets run down by Final Hour, Silver Bolts, and Condemn. |
Levels 1-3 are skill-based: MF's Double Up poke punishes sloppy CS, but if you Tumble to break minion bounce lines and only trade on her Q cooldown, you farm even.
The full Vayne vs Miss Fortune report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Miss Fortune vs Vayne guide →
All Vayne bot lane (adc) matchups →