How to win lane as Miss Fortune against Vayne · 53.95% win rate over 5,038 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Miss Fortune | You win level 1 because Double Up out-ranges Vayne's short auto and she has no poke to contest it. |
| Level 2 | Miss Fortune | At level 2 your extra Strut and Q pressure let you punish every step-up while she still can't waveclear. |
| Level 3 | Miss Fortune | Level 3 favours you as full Q-E-Strut out-trades her before Silver Bolts scaling exists. |
| Levels 4-5 | Miss Fortune | Through levels 4-5 you keep the range and DPS edge while she has no items to threaten back. |
| Level 6 | Miss Fortune | At 6 Bullet Time plus support CC is an all-in Vayne can't cancel with Tumble or Condemn. |
| First item | Miss Fortune | At first item your Galeforce spike lands before Vayne's three-item power comes online. |
| Two+ items | Vayne | With two-plus items Final Hour's invisibility, movespeed, and true damage let Vayne out-scale and shred you. |
You win level 1-2 outright: Double Up out-ranges her 550 auto and she has zero poke or waveclear, so poke her off every last hit and set up a shove.
The full Miss Fortune vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Miss Fortune guide →
All Miss Fortune bot lane (adc) matchups →