How to win lane as Vayne against Samira · 49.6% win rate (8,275 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
A scaling mirror where your true damage cheats — survive the lane evenly and out-duel everything past two items.
Track: Samira's W — Blade Whirl (30–22s cooldown). Deletes every projectile for a second — hold your key shots until the whirl is spent.
Read from Vayne's seat: which stage windows this plan plays for against Samira.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is even as neither of you has a committal all-in yet. |
| Level 2 | Even / skill | Level 2 stays skill-based with her poke offset by your Tumble spacing. |
| Level 3 | Even / skill | Level 3 remains a coin-flip decided by whether you deny her E-dash range. |
| Levels 4-5 | Even / skill | Levels 4-5 stay even, her melee threat balanced by your kiting. |
| Level 6 | Samira | Level 6 favors Samira because Inferno Trigger plus support CC is a lethal all-in you can't yet answer. |
| First item | Samira | First item favors Samira as her Shieldbow lifesteal and reset burst peak before your scaling. |
| Two+ items | Vayne | At 2+ items you win: the melee-bound Samira gets kited and Condemned by Final Hour and Silver Bolts. |
Levels 1-4 are skill-based: Samira's Flair pokes but she needs melee to snowball, so if you Tumble to hold max range and hug minions you farm even and deny her dash gap-closes. She needs melee range to snowball, so hold your distance with Tumble and hug the minions while you farm. Trade only when her dash is already spent. Keep Condemn for the moment she closes, because a wall stun is the single thing in your kit that answers a committed Wild Rush.
Pooled Emerald+ win rates from Vayne's side, sampled July 2026.
The full Vayne vs Samira report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Nobody on paper — a 49.6% win rate over 8,275 games makes this a coin flip decided by play, not champion select.
Yes — Vayne vs Samira is a genuine skill matchup: 49.6% win rate, and the favour swings window to window rather than being set at champion select.
No hard counter either way — the Vayne vs Samira win rate is 49.6%, an even lane decided by execution.
Vayne takes Lethal Tempo on the Precision tree with Triumph, Legend: Bloodline and Coup de Grace, and Domination secondary (Taste of Blood and Treasure Hunter) vs Samira.
Start Doran's Blade + Health Potion and back for Cutlass / Recurve (≈1000g). Build Blade of the Ruined King first, then Guinsoo's / Terminus, with Plated Steelcaps / Berserker's.
Playing the other side? Samira vs Vayne guide →
All Vayne bot lane matchups →
More Vayne bot lane matchups: vs Lucian · vs Miss Fortune · vs Nilah · vs Senna · vs Seraphine · vs Sivir