Vayne vs Nilah — Bot Lane (ADC) Matchup Guide

How to win lane as Vayne against Nilah · 48.37% win rate over 1,015 Emerald+ games · Updated 2026-07-27

Verdict: Nilah is favoured — Nilah owns 6 of the 7 game windows to Vayne's 1. Play it patient and win your windows. Vayne wins 48.37% of games vs Nilah in bot lane (adc) (1,015 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1NilahLevel 1 favors Nilah; her doubled healing and lifesteal win the melee trade outright.
Level 2NilahLevel 2 stays Nilah's as Slipstream dodge frames let her trade for free.
Level 3NilahLevel 3 is hers because Jubilant Veil negates your autos in every exchange.
Levels 4-5NilahLevels 4-5 remain Nilah-favored with her sustain still out-trading your fragile frame.
Level 6NilahLevel 6 favors Nilah since Apotheosis plus support CC is an all-in you can't yet survive.
First itemNilahFirst item stays Nilah's as her Shieldbow/Bloodthirster sustain spike out-trades your single item.
Two+ itemsVayneAt 2+ items you win: Silver Bolts' true damage finally out-paces her healing and you kite her melee range.

Early game (levels 1–5)

Levels 1-2 belong to Nilah: her doubled healing and Slipstream lifesteal win any melee-range exchange, so give ground, farm at max range, and Condemn her the moment she dashes in.

Read the rest of this matchup

The full Vayne vs Nilah report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Playing the other side? Nilah vs Vayne guide →
All Vayne bot lane (adc) matchups →