How to win lane as Vayne against Seraphine · 50.17% win rate over 6,673 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Level 1 is even because neither of you has a real trade tool yet and it's a skill CS lane. |
| Level 2 | Even / skill | Level 2 stays skill-based as Seraphine's Q poke is answered by your ability to farm on the move. |
| Level 3 | Even / skill | Level 3 is even since her root isn't reliably online yet and you can tumble her harass. |
| Levels 4-5 | Seraphine | Levels 4-5 favour Seraphine because her Beat Drop root plus support engage out-threatens your all-in. |
| Level 6 | Seraphine | Level 6 favours Seraphine because Encore can charm-lock you for a bot-lane collapse. |
| First item | Vayne | First item favours Vayne because Silver Bolts melts her low base health once your DPS spike is online. |
| Two+ items | Vayne | 2+ items favour Vayne because you hyper-carry and she has no way to escape your kiting. |
Levels 1-3 are even and skill-based: Seraphine wants to poke with Q and zone your CS, but she has no hard lockdown yet, so respect her mana-efficient harass and farm safely without ever eating a free High Note. Trade only when her Q is on cooldown and you can tumble in for a clean auto reset.
The full Vayne vs Seraphine report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
Become a Founding Member — $1.99/month →🔒 Secure checkout · 💰 7-day money-back guarantee · ✋ Cancel anytime
Early Access price — $3.99/month for new members after launch.
Playing the other side? Seraphine vs Vayne guide →
All Vayne bot lane (adc) matchups →