The champions that counter Seraphine hardest in bot lane are Ziggs (46.81%), Senna (48.33%) and Tristana (49.19%) — those are Seraphine's own pooled win rates. The easiest matchups are Draven (54.27%), Corki (54.08%) and Varus (53.96%).
29 researched matchup guides for Seraphine in bot lane, most-played first. Win rates are Seraphine's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Seraphine vs Caitlyn | 52.8% | 32,678 | Leans Seraphine |
| Seraphine vs Jhin | 50.75% | 29,235 | Leans Seraphine |
| Seraphine vs Ezreal | 53.69% | 26,319 | Leans Seraphine |
| Seraphine vs Kai'Sa | 52.67% | 22,058 | Leans Seraphine |
| Seraphine vs Jinx | 50.07% | 21,481 | Even |
| Seraphine vs Ashe | 50.41% | 18,825 | Even |
| Seraphine vs Senna | 48.33% | 16,735 | Leans Senna |
| Seraphine vs Lucian | 52.44% | 14,912 | Leans Seraphine |
| Seraphine vs Tristana | 49.19% | 13,069 | Leans Tristana |
| Seraphine vs Miss Fortune | 50.33% | 12,564 | Even |
| Seraphine vs Aphelios | 52.86% | 10,428 | Leans Seraphine |
| Seraphine vs Twitch | 49.38% | 9,971 | Even |
| Seraphine vs Smolder | 50.7% | 9,781 | Even |
| Seraphine vs Sivir | 51.04% | 8,943 | Leans Seraphine |
| Seraphine vs Ziggs | 46.81% | 8,908 | Leans Ziggs |
| Seraphine vs Samira | 49.6% | 8,792 | Even |
| Seraphine vs Vayne | 50.37% | 8,697 | Even |
| Seraphine vs Draven | 54.27% | 7,999 | Leans Seraphine |
| Seraphine vs Zeri | 50.31% | 6,853 | Even |
| Seraphine vs Xayah | 51.59% | 5,913 | Leans Seraphine |
| Seraphine vs Varus | 53.96% | 5,239 | Leans Seraphine |
| Seraphine vs Kalista | 53.64% | 3,542 | Leans Seraphine |
| Seraphine vs Kog'Maw | 50.08% | 3,233 | Even |
| Seraphine vs Veigar | 49.27% | 3,083 | Even |
| Seraphine vs Swain | 51.96% | 2,810 | Leans Seraphine |
| Seraphine vs Nilah | 50.66% | 2,268 | Even |
| Seraphine vs Corki | 54.08% | 1,925 | Leans Seraphine |
| Seraphine vs Karthus | 49.84% | 1,545 | Even |
| Seraphine vs Heimerdinger | 53.39% | 783 | Leans Seraphine |