How to win lane as Seraphine against Karthus · 55.79% win rate over 561 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Seraphine | Karthus is immobile and Q-reliant, so your level-1 poke wins. |
| Level 2 | Seraphine | At level 2 your Q/E out-trade his fragile early body. |
| Level 3 | Seraphine | Level 3 lets you all-in him before his AP scaling arrives. |
| Levels 4-5 | Even / skill | Level 4 is even as his Defile and your poke balance out. |
| Level 6 | Karthus | Level 6 tilts to him: Requiem and Death Defiance grow his threat. |
| First item | Karthus | First AP item makes his Lay Waste and Defile out-damage you. |
| Two+ items | Karthus | Late game his AoE zoning and global burst hard-outscale you. |
You win levels 1-3: Karthus is immobile and depends on landing Lay Waste, so your longer-uptime Q poke and E slow out-trade him and punish his fragile early body whenever his Q is down.
The full Seraphine vs Karthus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karthus vs Seraphine guide →
All Seraphine bot lane (adc) matchups →