How to win lane as Karthus against Seraphine · 53.56% win rate over 984 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Seraphine | Level 1 Seraphine out-ranges you with Q poke while W keeps her healthy. |
| Level 2 | Seraphine | Level 2 her W shield-and-heal sustains through your shorter-range trades. |
| Level 3 | Seraphine | Level 3 her Q plus E Beat Drop root out-pressures your farming setup. |
| Levels 4-5 | Karthus | Levels 4-5 your W-into-E zone finally out-trades her single Q casts. |
| Level 6 | Karthus | R Requiem gives a global execute she can't shield or heal through. |
| First item | Karthus | First-item Defile shreds her squishy immobile frame faster than she sustains. |
| Two+ items | Karthus | In 2+ item fights your zone and global ult beat her grouped AoE carry. |
Levels 1-3 Seraphine wins with range and sustain: Q pokes you down while W shields and heals keep her topped, and E roots you if you're slowed, so play safe, dodge her E setup, and just farm with Q.
The full Karthus vs Seraphine report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Seraphine vs Karthus guide →
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