How to win lane as Seraphine against Vayne · 52.17% win rate over 2,024 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Seraphine | You out-range and out-poke Vayne at level 1 with no risk. |
| Level 2 | Seraphine | Your level 2 E-Q trade chunks a champion with no lane presence. |
| Level 3 | Seraphine | At level 3 your full combo plus support CC threatens a kill she can't answer. |
| Levels 4-5 | Seraphine | Levels 4-5 you keep zoning her off farm while she has no trade-back. |
| Level 6 | Seraphine | Level 6 Encore's AoE charm makes a clean all-in Vayne cannot Tumble out of. |
| First item | Vayne | At one item Vayne's Silver Bolts and DPS overtake your poke-based lead. |
| Two+ items | Vayne | Late game Vayne's invisibility and Q resets let her run you down in fights. |
You dominate levels 1-5: your E-Q poke and superior range punish Vayne every time she steps up to CS, and she has no early tools to answer. Zone her off the wave and keep her low.
The full Seraphine vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Seraphine guide →
All Seraphine bot lane (adc) matchups →