How to win lane as Seraphine against Vayne · 50.37% win rate (8,697 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Her DPS needs fights your charm postpones — poke the notes, sustain the chip, and encore the all-in backward.
Track: Vayne's E — Condemn (20–12s cooldown). Wall-stuns you — never fight her with terrain at your back.
Read from Seraphine's seat: which stage windows this plan plays for against Vayne.
This is Seraphine's own plan; across 8,697 pooled games the lane is even.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Seraphine | You out-range and out-poke Vayne at level 1 with no risk. |
| Level 2 | Seraphine | Your level 2 E-Q trade chunks a champion with no lane presence. |
| Level 3 | Seraphine | At level 3 your full combo plus support CC threatens a kill she can't answer. |
| Levels 4-5 | Seraphine | Levels 4-5 you keep zoning her off farm while she has no trade-back. |
| Level 6 | Seraphine | Level 6 Encore's AoE charm makes a clean all-in Vayne cannot Tumble out of. |
| First item | Vayne | At one item Vayne's Silver Bolts and DPS overtake your poke-based lead. |
| Two+ items | Vayne | Late game Vayne's invisibility and Q resets let her run you down in fights. |
You dominate levels 1-5: your E-Q poke and superior range punish Vayne every time she steps up to CS, and she has no early tools to answer. Zone her off the wave and keep her low. She has no answer to your range at all, so poke her at every last-hit and keep her low while the notes build. Beat Drop into your support's engage is a kill she cannot tumble out of. Stay off the lane walls yourself and take the plate rather than chasing her under tower.
Pooled Emerald+ win rates from Seraphine's side, sampled July 2026.
The full Seraphine vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Nobody on paper — a 50.37% win rate over 8,697 games makes this a coin flip decided by play, not champion select.
Yes — Seraphine vs Vayne is a genuine skill matchup: 50.37% win rate, and the favour swings window to window rather than being set at champion select.
No hard counter either way — the Seraphine vs Vayne win rate is 50.37%, an even lane decided by execution.
Seraphine takes Summon Aery on the Sorcery tree with Manaflow Band, Transcendence and Scorch, and Inspiration secondary (Biscuit Delivery and Cosmic Insight) vs Vayne.
Start Doran's Ring + 2 Health Potions and back for Lost Chapter (≈1300g). Build Luden's / Moonstone by build first, then Rylai's, with Plated Steelcaps / Sorcerer's.
Playing the other side? Vayne vs Seraphine guide →
All Seraphine bot lane matchups →
More Seraphine bot lane matchups: vs Tristana · vs Twitch · vs Varus · vs Veigar · vs Xayah · vs Zeri