How to win lane as Vayne against Ezreal · 55.98% win rate over 9,126 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Ezreal | Ezreal's Mystic Shot poke out-harasses melee-range Vayne at level 1. |
| Level 2 | Ezreal | At 2 his range plus Manaflow harass keeps chipping you off CS. |
| Level 3 | Ezreal | Level 3 Arcane Shift means you can't punish his poke. |
| Levels 4-5 | Ezreal | Through 4-5 constant skillshot poke denies your stacks and CS. |
| Level 6 | Ezreal | His level 6 Trueshot Barrage out-values a stack-hungry Final Hour. |
| First item | Vayne | By one item your reset stacking overtakes his falling-off poke. |
| Two+ items | Vayne | With two-plus items Vayne's true damage shreds an escape-spent Ezreal. |
Ezreal harasses you with Mystic Shot every time you go for CS and Arcane Shift keeps him untouchable; last-hit from behind minions, dodge his skillshots, and don't try to trade into his poke.
The full Vayne vs Ezreal report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Ezreal vs Vayne guide →
All Vayne bot lane (adc) matchups →