Vayne vs Kalista — Bot Lane (ADC) Matchup Guide

How to win lane as Vayne against Kalista · 53.24% win rate over 1,326 Emerald+ games · Updated 2026-07-27

Verdict: Winnable despite the lane — Kalista owns 2 of the 7 game windows to Vayne's 1, yet the win rate favours Vayne: survive their windows and the game is yours. Vayne wins 53.24% of games vs Kalista in bot lane (adc) (1,326 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1Even / skillLevel 1 is even as both poke and farm without a committal threat.
Level 2Even / skillLevel 2 stays a skill lane before Rend stacks or items come online.
Level 3Even / skillLevel 3 remains even with neither holding a decisive all-in.
Levels 4-5Even / skillLevels 4-5 stay even until her Rend stacks and DPS fully ramp.
Level 6KalistaAt Level 5-6 window her Rend execute and Fate's Call give her the trading edge.
First itemKalistaAt first item her spear DPS and Rend spike out-trade a still-ramping Vayne.
Two+ itemsVayneBy two-plus items Silver Bolts and a Condemn on Fate's Call flip the duel to Vayne.

Early game (levels 1–5)

Levels 1-4 are an even skill lane: Kalista pokes with spears and kites, but without full Rend stacks or an item she can't hard-commit, so match her CS and dodge Pierce.

Read the rest of this matchup

The full Vayne vs Kalista report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Playing the other side? Kalista vs Vayne guide →
All Vayne bot lane (adc) matchups →